1. Higher Frequency of Reflux Symptoms and Acid-Related Dyspepsia in Women than Men Regardless of Endoscopic Esophagitis: Analysis of 3,505 Japanese Subjects Undergoing Medical Health Checkups
- Author
-
Hirohatu Kawakubo, Yoichiro Ito, Motoyasu Kusano, Yasuhisa Sakata, Takashi Ohyama, Keiji Matsunaga, Kayo Akutagawa, Megumi Hara, Kazuma Fujimoto, Ryuichi Iwakiri, Hiroyoshi Endo, Natsuko Sakata, Tomomi Yoshioka, Nanae Tsuruoka, Eri Takeshita, Yuichiro Tanaka, and Shimpei Shirai
- Subjects
Adult ,Male ,medicine.medical_specialty ,Cross-sectional study ,Physical examination ,Severity of Illness Index ,Gastroenterology ,Endoscopy, Gastrointestinal ,Barrett Esophagus ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Japan ,Risk Factors ,Sex factors ,Surveys and Questionnaires ,Internal medicine ,Severity of illness ,medicine ,Humans ,Dyspepsia ,Reflux esophagitis ,Esophagitis, Peptic ,Physical Examination ,medicine.diagnostic_test ,business.industry ,Age Factors ,Reflux ,Middle Aged ,medicine.disease ,Cross-Sectional Studies ,Hernia, Hiatal ,030220 oncology & carcinogenesis ,Gastroesophageal Reflux ,Female ,030211 gastroenterology & hepatology ,Medical health ,business ,Esophagitis - Abstract
Background/Aims: This study aimed at (i) clarifying the factors associated with high scores on the modified frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) among 3,505 relatively healthy subjects undergoing routine medical health checkups with gastrointestinal endoscopy and (ii) comparing risk factors for high FSSG scores between subjects with and without reflux esophagitis. Methods: In total, 3,505 subjects (male/female: 1,922/1,583) who underwent upper gastrointestinal endoscopy during health medical checkups at 5 hospitals in Saga, Japan from January 2013 to December 2013 were enrolled. All subjects completed a modified FSSG questionnaire, which comprised 7 questions regarding reflux symptoms and 7 questions regarding acid-related dyspepsia. Each question was assigned a score based on the frequency of symptoms. Results: Younger age, female gender, hiatal herniation, and endoscopic reflux esophagitis were risk factors for a FSSG score with a high total. Subjects with high scores but without esophagitis were women, and hiatal herniation and Barrett's esophagus were frequently seen in patients with reflux esophagitis. Conclusion: Younger age, female gender, hiatal hernia, and endoscopic esophagitis were risk factors for a high FSSG score, and women tended to complain of upper gastrointestinal symptoms more frequently than did men among subjects without endoscopic esophagitis.
- Published
- 2016