1. Characterization of a novel Lbx1 mouse loss of function strain
- Author
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Lyvianne Decourtye, Jeremy A. McCallum-Loudeac, Sylvia Zellhuber-McMillan, Emma Young, Kathleen J. Sircombe, and Megan J. Wilson
- Subjects
Homeodomain Proteins ,Cancer Research ,Mice ,Phenotype ,Scoliosis ,Animals ,Cell Biology ,Molecular Biology ,Polymorphism, Single Nucleotide ,Developmental Biology ,Transcription Factors - Abstract
Adolescent Idiopathic Scoliosis (AIS) is the most common type of spine deformity affecting 2-3% of the population worldwide. The etiology of this disease is still poorly understood. Several GWAS studies have identified single nucleotide polymorphisms (SNPs) located near the gene LBX1 that is significantly correlated with AIS risk. LBX1 is a transcription factor with roles in myocyte precursor migration, cardiac neural crest specification, and neuronal fate determination in the neural tube. Here, we further investigated the role of LBX1 in the developing spinal cord of mouse embryos using a CRISPR-generated mouse model expressing a truncated version of LBX1 (Lbx1
- Published
- 2021