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Glomeruli are interconnected capillaries in the renal cortex that are responsible for blood filtration. Damage to these glomeruli often signifies the presence of kidney disorders like glomerulonephritis and glomerulosclerosis, which can ultimately lead to chronic kidney disease and kidney failure. The timely detection of such conditions is essential for effective treatment. This paper proposes a modified UNet model to accurately detect glomeruli in whole-slide images of kidney tissue. The UNet model was modified by changing the number of filters and feature map dimensions from the first to the last layer to enhance the model's capacity for feature extraction. Moreover, the depth of the UNet model was also improved by adding one more convolution block to both the encoder and decoder sections. The dataset used in the study comprised 20 large whole-side images. Due to their large size, the images were cropped into 512 × 512-pixel patches, resulting in a dataset comprising 50,486 images. The proposed model performed well, with 95.7% accuracy, 97.2% precision, 96.4% recall, and 96.7% F1-score. These results demonstrate the proposed model's superior performance compared to the original UNet model, the UNet model with EfficientNetb3, and the current state-of-the-art. Based on these experimental findings, it has been determined that the proposed model accurately identifies glomeruli in extracted kidney patches. [ABSTRACT FROM AUTHOR]

The segmentation of gastrointestinal (GI) organs is crucial in radiation therapy for treating GI cancer. It allows for developing a targeted radiation therapy plan while minimizing radiation exposure to healthy tissue, improving treatment success, and decreasing side effects. Medical diagnostics in GI tract organ segmentation is essential for accurate disease detection, precise differential diagnosis, optimal treatment planning, and efficient disease monitoring. This research presents a hybrid encoder–decoder-based model for segmenting healthy organs in the GI tract in biomedical images of cancer patients, which might help radiation oncologists treat cancer more quickly. Here, EfficientNet B0 is used as a bottom-up encoder architecture for downsampling to capture contextual information by extracting meaningful and discriminative features from input images. The performance of the EfficientNet B0 encoder is compared with that of three encoders: ResNet 50, MobileNet V2, and Timm Gernet. The Feature Pyramid Network (FPN) is a top-down decoder architecture used for upsampling to recover spatial information. The performance of the FPN decoder was compared with that of three decoders: PAN, Linknet, and MAnet. This paper proposes a segmentation model named as the Feature Pyramid Network (FPN), with EfficientNet B0 as the encoder. Furthermore, the proposed hybrid model is analyzed using Adam, Adadelta, SGD, and RMSprop optimizers. Four performance criteria are used to assess the models: the Jaccard and Dice coefficients, model loss, and processing time. The proposed model can achieve Dice coefficient and Jaccard index values of 0.8975 and 0.8832, respectively. The proposed method can assist radiation oncologists in precisely targeting areas hosting cancer cells in the gastrointestinal tract, allowing for more efficient and timely cancer treatment. [ABSTRACT FROM AUTHOR]

Acute Lymphocytic Leukemia is a type of cancer that occurs when abnormal white blood cells are produced in the bone marrow which do not function properly, crowding out healthy cells and weakening the immunity of the body and thus its ability to resist infections. It spreads quickly in children's bodies, and if not treated promptly it may lead to death. The manual detection of this disease is a tedious and slow task. Machine learning and deep learning techniques are faster than manual detection and more accurate. In this paper, a deep feature selection-based approach ResRandSVM is proposed for the detection of Acute Lymphocytic Leukemia in blood smear images. The proposed approach uses seven deep-learning models: ResNet152, VGG16, DenseNet121, MobileNetV2, InceptionV3, EfficientNetB0 and ResNet50 for deep feature extraction from blood smear images. After that, three feature selection methods are used to extract valuable and important features: analysis of variance (ANOVA), principal component analysis (PCA), and Random Forest. Then the selected feature map is fed to four different classifiers, Adaboost, Support Vector Machine, Artificial Neural Network and Naïve Bayes models, to classify the images into leukemia and normal images. The model performs best with a combination of ResNet50 as a feature extractor, Random Forest as feature selection and Support Vector Machine as a classifier with an accuracy of 0.900, precision of 0.902, recall of 0.957 and F1-score of 0.929. [ABSTRACT FROM AUTHOR]

The segmentation of lungs from medical images is a critical step in the diagnosis and treatment of lung diseases. Deep learning techniques have shown great promise in automating this task, eliminating the need for manual annotation by radiologists. In this research, a convolution neural network architecture is proposed for lung segmentation using chest X-ray images. In the proposed model, concatenate block is embedded to learn a series of filters or features used to extract meaningful information from the image. Moreover, a transpose layer is employed in the concatenate block to improve the spatial resolution of feature maps generated by a prior convolutional layer. The proposed model is trained using k-fold validation as it is a powerful and flexible tool for evaluating the performance of deep learning models. The proposed model is evaluated on five different subsets of the data by taking the value of k as 5 to obtain the optimized model to obtain more accurate results. The performance of the proposed model is analyzed for different hyper-parameters such as the batch size as 32, optimizer as Adam and 40 epochs. The dataset used for the segmentation of disease is taken from the Kaggle repository. The various performance parameters such as accuracy, IoU, and dice coefficient are calculated, and the values obtained are 0.97, 0.93, and 0.96, respectively. [ABSTRACT FROM AUTHOR]

Brain tumor diagnosis at an early stage can improve the chances of successful treatment and better patient outcomes. In the biomedical industry, non-invasive diagnostic procedures, such as magnetic resonance imaging (MRI), can be used to diagnose brain tumors. Deep learning, a type of artificial intelligence, can analyze MRI images in a matter of seconds, reducing the time it takes for diagnosis and potentially improving patient outcomes. Furthermore, an ensemble model can help increase the accuracy of classification by combining the strengths of multiple models and compensating for their individual weaknesses. Therefore, in this research, a weighted average ensemble deep learning model is proposed for the classification of brain tumors. For the weighted ensemble classification model, three different feature spaces are taken from the transfer learning VGG19 model, Convolution Neural Network (CNN) model without augmentation, and CNN model with augmentation. These three feature spaces are ensembled with the best combination of weights, i.e., weight1, weight2, and weight3 by using grid search. The dataset used for simulation is taken from The Cancer Genome Atlas (TCGA), having a lower-grade glioma collection with 3929 MRI images of 110 patients. The ensemble model helps reduce overfitting by combining multiple models that have learned different aspects of the data. The proposed ensemble model outperforms the three individual models for detecting brain tumors in terms of accuracy, precision, and F1-score. Therefore, the proposed model can act as a second opinion tool for radiologists to diagnose the tumor from MRI images of the brain. [ABSTRACT FROM AUTHOR]