1. Computer-aided diagnosis system for characterizing ISUP grade≥2 prostate cancers at multiparametric MRI: A cross-vendor evaluation
- Author
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Luc Cormier, R. de Rozario, C. Gonindard-Melodelima, Olivier Rouvière, S. Transin, M. Funes De La Vega, Paul Walker, Romaric Loffroy, Rémi Souchon, Service de radiologie et d'Imagerie médicale diagnostique et thérapeutique (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Application des ultrasons à la thérapie (LabTAU), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre Léon Bérard [Lyon]-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Ecologie Alpine (LECA ), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire d'Electronique, d'Informatique et d'Image [EA 7508] (Le2i), Université de Technologie de Belfort-Montbeliard (UTBM)-Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Service de RMN Spectroscopie, Médecine Nucléaire (CHU de Dijon), Service de Pathologie [CHU de Dijon], Service d'Urologie [CHU de Dijon], Department of Urinary and Vascular Radiology, Hospices Civils de Lyon (HCL), ANR-17-RHUS-0006,PERFUSE,Personalized Focused Ultrasound Surgery of Localized Prostate Cancer(2017), CCSD, Accord Elsevier, Personalized Focused Ultrasound Surgery of Localized Prostate Cancer - - PERFUSE2017 - ANR-17-RHUS-0006 - RHUS - VALID, Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Arts et Métiers Sciences et Technologies, and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Male ,Standards ,medicine.medical_specialty ,Computer-assisted diagnosis ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,medicine.medical_treatment ,Diagnostic accuracy ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,Sensitivity and Specificity ,[SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Prostate ,Diagnosis ,Validation ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Magnetic resonance imaging (MRI) ,Diagnosis, Computer-Assisted ,Multiparametric Magnetic Resonance Imaging ,Aged ,Retrospective Studies ,Prostatectomy ,Peripheral zone ,Radiological and Ultrasound Technology ,Receiver operating characteristic ,business.industry ,PI-RADS V2 ,Multiparametric MRI ,Prostatic Neoplasms ,General Medicine ,Confidence interval ,3. Good health ,[SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging ,medicine.anatomical_structure ,Computer-aided diagnosis ,030220 oncology & carcinogenesis ,Cohort ,Images ,Radiology ,business - Abstract
International audience; Purpose: To assess the performance of a computer-aided diagnosis (CADx) system trained at characterizing International Society of Urological Pathology (ISUP) grade >= 2 peripheral zone (PZ) prostate cancers on multiparametric magnetic resonance imaging (mpMRI) examinations from a different institution and acquired on different scanners than those used for the training database.Patients and methods: Preoperative mpMRIs of 74 men (median age, 65.7 years) treated by prostatectomy between 2014 and 2017 were retrospectively selected. One radiologist outlined suspicious lesions and scored them using Prostate Imaging-Reporting and Data System version 2 (PI-RADSv2); their CADx score was calculated using a classifier trained on an independent database of 106 patients treated by prostatectomy in another institution. The lesions' nature was assessed by comparison with prostatectomy whole-mounts. Diagnostic accuracy was estimated with areas under receiver operating characteristic curves (AUCs). Sensitivity and specificity were calculated using a CADx threshold (>= 0.21) that yielded 95% sensitivity in the training database, and a PI-RADSv2 >= 3 threshold.Results: A total of 127 lesions (PZ, n = 104; transition zone [TZ], n = 23) were described. In PZ, CADx and PI-RADSv2 scores had similar AUCs for characterizing ISUP grade >= 2 cancers (0.78 [95% confidence interval (CI): 0.69-0.87] vs. 0.74 [95%CI: 0.62-0.82], respectively) (P = 0.59). Sensitivity and specificity were respectively 89% (95%CI: 82-97%) and 42% (95%CI: 26-58%) for the CADx score, and 97% (95%CI: 93-100%) and 37% (95%CI: 22-52%) for the PI-RADSv2 score. In TZ, both scores showed poor specificity.Conclusion: In this external cohort, the CADx and PI-RADSv2 scores showed similar performances in characterizing ISUP grade >= 2 cancers. (C) 2019 Societe francaise de radiologie. Published by Elsevier Masson SAS. All rights reserved.
- Published
- 2019
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