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Your search keyword '"Tönjes, A."' showing total 49 results
Start Over Author "Tönjes, A." Journal diabetologie und stoffwechsel
49 results on '"Tönjes, A."'

2. Genetic dissection of serum vaspin highlights its causal role in lipid metabolism

Author

Marleen Würfel, Katrin Horn, Diana Le Duc, Akhil Velluva, Carola Marzi, Harald Grallert, Nele Friedrich, Maik Pietzner, Uwe Völker, Henry Völzke, Emma Ahlqvist, Dina Mansour Aly, Tiinamaija Tuomi, Ronny Baber, Jürgen Kratzsch, Joachim Thiery, Berend Isermann, Markus Löffler, Nora Klöting, Matthias Blüher, Michael Stumvoll, John T. Heiker, Anke Tönjes, Markus Scholz, Peter Kovacs, and Jana Breitfeld

Published
2023
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5. The adipokine WISP1 is decreased in human and murine chronic kidney disease due to urinary and dialysate losses

Author

Hoffmann, Annett, additional, Kralisch, Susan, additional, Wendt, Ralph, additional, Klöting, Nora, additional, Pivovarova-Ramich, Olga, additional, Rudovich, Natalia, additional, Beige, Joachim, additional, Bachmann, Anette, additional, Blüher, Matthias, additional, Hankir, Mohammed K, additional, Kovacs, Peter, additional, Stumvoll, Michael, additional, Tönjes, Anke, additional, and Ebert, Thomas, additional

Published
2022
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12. Circulating betatrophin is increased in type 2 and gestational diabetes mellitus

Author

Anne Hoffmann, Juergen Kratzsch, Ulrike Lossner, Matthias Blüher, A Tönjes, Mathias Fasshauer, Michael Stumvoll, Ulrike Wurst, Susan Kralisch, and Thomas Ebert

Subjects
medicine.medical_specialty, endocrine system diseases, business.industry, Betatrophin, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, nutritional and metabolic diseases, Adipokine, Type 2 Diabetes Mellitus, medicine.disease, Gestational diabetes, Insulin resistance, Endocrinology, Adipogenesis, Diabetes mellitus, Internal medicine, medicine, business
Abstract

Objective: Betatrophin has recently been introduced as a novel adipokine/hepatokine which promotes pancreatic β cell proliferation and improves glucose tolerance in several mouse models of insulin resistance. However, regulation of betatrophin in subjects with diabetes mellitus in vivo and in adipocytes in vitro has not been thoroughly determined. Design and Methods: Circulating betatrophin was quantified by ELISA in patients with type 2 diabetes mellitus (T2DM) and in women with gestational diabetes mellitus (GDM) as compared to controls. Moreover, the effects of insulin resistance-inducing hormones and differentiation on betatrophin mRNA production in 3T3-L1 adipocytes were investigated in vitro. Results: Median [interquartile range] serum betatrophin levels were higher in patients with T2DM (1.19 [0.37] µg/l) as compared with nondiabetic subjects (1.03 [0.47] µg/l) (P = 0.005). Furthermore, median serum betatrophin levels were higher in women with GDM (1.79 [0.53] µg/l) as compared to non-diabetic gestational age-matched controls (1.58 [0.44] µg/l) (P = 0.002). Moreover, betatrophin mRNA expression was significantly induced by insulin and during adipogenesis in 3T3-L1 adipocytes in vitro whereas its synthesis was not influenced by interleukin-6, interleukin-1β, isoproterenol, dexamethasone, and growth hormone. Conclusions: Circulating betatrophin is increased in T2DM and GDM in vivo. Insulin-induced betatrophin mRNA expression in adipocytes might contribute to this effect. Further studies need to elucidate the pathophysiological significance of betatrophin upregulation in T2DM and GDM.

Published
2015
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13. The role of VEGFA in regulation of fat distribution

Author

Dorit Schleinitz, Matthias Kern, A Tönjes, M Quandt, Matthias Blüher, Nora Klöting, B Gutsmann, Peter Kovacs, J Krüger, Jana Breitfeld, and Michael Stumvoll

Subjects
medicine.medical_specialty, Vascular endothelial growth factor A, Endocrinology, Endocrinology, Diabetes and Metabolism, Internal medicine, medicine, Fat distribution, Biology
Published
2015
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15. Genome wide meta-analysis identifies novel regulators of circulating serum progranulin

Author

Krüger, J, primary, Scholz, M, additional, Gross, A, additional, Krause, K, additional, Marzi, C, additional, Grallert, H, additional, Ladenvall, C, additional, Schleinitz, D, additional, Kirsten, H, additional, Heyne, H, additional, Laurila, E, additional, Kriebel, J, additional, Thorand, B, additional, Rathmann, W, additional, Groop, L, additional, Prokopenko, I, additional, Isomaa, B, additional, Beutner, F, additional, Kratzsch, J, additional, Thiery, J, additional, Klöting, N, additional, Fischer-Rosinský, A, additional, Pfeiffer, A, additional, Spranger, J, additional, Gieger, C, additional, Blüher, M, additional, Stumvoll, M, additional, Kovacs, P, additional, and Tönjes, A, additional

Published
2016
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20. Vaspin reguliert die Insulinsensitivität

Author

Michael Stumvoll, Kerstin Dietrich, I Müller, N Wiele, Jana Breitfeld, A Tönjes, Dorit Schleinitz, Matthias Blüher, U Enigk, John T. Heiker, M Prellberg, Peter Kovacs, B. Enigk, Matthias Kern, Yvonne Böttcher, AG Beck-Sickinger, and Nora Klöting

Subjects
Endocrinology, Diabetes and Metabolism
Published
2011
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21. Metabolic and genetic predictors of circulating adipocyte fatty acid-binding protein

Author

J Richter, Michael Stumvoll, Peter Kovacs, Matthias Blüher, Mathias Fasshauer, U Lößner, A Tönjes, and Susan Kralisch

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, Endocrinology, Diabetes and Metabolism, Population, Renal function, Adipokine, Single-nucleotide polymorphism, medicine.disease, chemistry.chemical_compound, Endocrinology, Insulin resistance, chemistry, Adipocyte, Internal medicine, medicine, Glucose homeostasis, Metabolic syndrome, education, business
Abstract

Aims: Adipocyte fatty acid-binding protein (AFABP) was recently introduced as a novel adipokine playing an important role in glucose homeostasis. In the current study, we investigated the relationship between serum AFABP levels and metabolic, as well as cardiovascular parameters, in the self-contained population of Sorbs. Furthermore, we analyzed the effects of common variants in the FABP4 gene on AFABP serum concentration. Methods: Serum AFABP concentrations were quantified by ELISA and correlated with metabolic and cardiovascular parameters, as well as inflammatory markers and renal function in 868 well-characterized non-diabetic Sorbs from Germany. Results: Median AFABP serum concentrations were 1.5-fold higher in female subjects (23.03µg/l) as compared to males (15.86µg/l). Waist-to-height-ratio and glomerular filtration rate were independently associated with AFABP concentrations in multiple regression analysis in both females and males. In females, the number of children born was a positive predictor of circulating AFABP independent of body fat mass. Two single nucleotide polymorphisms, rs16909187 and rs10808846 representing common genetic variation in FABP4 did not show any effects on serum AFABP concentrations in our study cohort. Conclusion: AFABP serum concentrations are determined by parameters of fat distribution, renal function, gender, and potentially number of pregnancies. Keywords: AFABP, Cardiovascular Diseases, Insulin Resistance, Metabolic Syndrome, Obesity, Renal Function

Published
2011
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24. The role of VEGFA in regulation of fat distribution

Author

Krüger, J, primary, Quandt, M, additional, Gutsmann, B, additional, Schleinitz, D, additional, Breitfeld, J, additional, Kern, M, additional, Klöting, N, additional, Tönjes, A, additional, Blüher, M, additional, Stumvoll, M, additional, and Kovacs, P, additional

Published
2015
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25. The role of BMP2 in the pathophysiology of obesity

Author

Unthan, M, primary, Guiu-Jurado, E, additional, Ruschke, K, additional, Schleinitz, D, additional, Kern, M, additional, Gutsmann, B, additional, Klöting, N, additional, Tönjes, A, additional, Stumvoll, M, additional, Kovacs, P, additional, and Blüher, M, additional

Published
2015
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31. Expression of the Bone Morphogenetic Protein Receptor 1A Gene (BMPR1A) in Adipose Tissue and BMPR1A Genetic Variation are Associated with Human Obesity

Author

H. Unbehauen, A Tönjes, Karen Ruschke, Y. H. Tseng, Michael Stumvoll, S. Wolf, Matthias Blüher, B. Enigk, Peter Kovacs, Yvonne Böttcher, Dorit Schleinitz, and Nora Klöting

Subjects
PRDM16, Bone morphogenetic protein 7, Bone morphogenetic protein 6, Endocrinology, Diabetes and Metabolism, GDF10, Adipose tissue, Bone morphogenetic protein receptor, Biology, BMPR1A, BMPR1B, Cell biology
Published
2008
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32. Association of FTO variants with BMI, fat mass and waist in the isolated population of Sorbs in Germany

Author

E. Zeggini, M. I. McCarthy, Peter Kovacs, N W Rayner, Dorit Schleinitz, D. Teupser, Michael Stumvoll, A Tönjes, B. Enigk, Knut Krohn, Andrew P. Morris, J. Thiery, Yvonne Böttcher, and Katrin Hoffmann

Subjects
medicine.medical_specialty, Isolated population, Endocrinology, Waist, business.industry, Endocrinology, Diabetes and Metabolism, Internal medicine, Medicine, business, Fat mass
Published
2008
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33. Near Normalization of Adhesion Molecule Plasma Concentrations after a 4-Weeks Physical Training Program in Patients with Abnormal Glucose Tolerance

Author

A. Oberbach, Juergen Kratzsch, A Tönjes, Michael Stumvoll, Matthias Blüher, F. Rassoul, and Nora Klöting

Subjects
Normalization (statistics), medicine.medical_specialty, Endocrinology, business.industry, Endocrinology, Diabetes and Metabolism, Abnormal glucose tolerance, Internal medicine, Plasma concentration, Medicine, In patient, business, Training program
Published
2006
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36. Funktionelle Relevanz der Stop-Codon Mutation rs61757459 in Vaspin (SerpinA12)

Author

Breitfeld, J, primary, Heiker, JT, additional, Böttcher, Y, additional, Schleinitz, D, additional, Tönjes, A, additional, Weidle, K, additional, Krause, K, additional, Küttner, EB, additional, Kieß, W, additional, Sträter, N, additional, Beck-Sickinger, AG, additional, Stumvoll, M, additional, Körner, A, additional, Blüher, M, additional, and Kovacs, P, additional

Published
2013
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40. Vaspin reguliert die Insulinsensitivität

Author

Breitfeld, J, primary, Klöting, N, additional, Heiker, J, additional, Enigk, U, additional, Kern, M, additional, Böttcher, Y, additional, Enigk, B, additional, Prellberg, M, additional, Müller, I, additional, Schleinitz, D, additional, Dietrich, K, additional, Wiele, N, additional, Tönjes, A, additional, Beck-Sickinger, AG, additional, Stumvoll, M, additional, Blüher, M, additional, and Kovacs, P, additional

Published
2011
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44. Selektion des FTO-Gens in menschlichen Populationen

Author

Dietrich, K, primary, Schröck, K, additional, Enigk, B, additional, Schleinitz, D, additional, Müller, I, additional, Krohn, K, additional, Stumvoll, M, additional, Kovacs, P, additional, Schöneberg, T, additional, and Tönjes, A, additional

Published
2009
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46. Bone Morphogenetic Protein Receptor 2 (BMPR2) mRNA Expression im Fettgewebe und genetische Varianten von BMPR2 sind mit humaner Adipositas assoziiert

Author

Schleinitz, D, primary, Klöting, N, additional, Böttcher, Y, additional, Berndt, J, additional, Wolf, S, additional, Ruschke, K, additional, Dietrich, K, additional, Koriath, M, additional, Enigk, B, additional, Scholz, GH, additional, Tseng, YH, additional, Tönjes, A, additional, Stumvoll, M, additional, Kovacs, P, additional, and Blüher, M, additional

Published
2009
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