Silvia Pardini, Piero A. Salvadori, Elena Sanguinetti, Marco Mainardi, Patricia Iozzo, Tiziana Liistro, Silvia Burchielli, Alessandro Vannucci, Sanguinetti, Elena, Liistro, Tiziana, Mainardi, Marco, Pardini, Silvia, Salvadori, Piero A, Vannucci, Alessandro, Burchielli, Silvia, and Iozzo, Patricia
Maternal obesity negatively affects fetal development. Abnormalities in brain glucose metabolism are predictive of metabolic-cognitive disorders.We studied the offspring (aged 0, 1, 6, 12 months) of minipigs fed a normal vs high-fat diet (HFD), by positron emission tomography (PET) to measure brain glucose metabolism, and ex vivo assessments of brain insulin receptors (IRβ) and GLUT4.At birth, brain glucose metabolism and IRβ were twice as high in the offspring of HFD-fed than control mothers. During infancy and youth, brain glucose uptake, GLUT4 and IRβ increased in the offspring of control mothers and decreased in those of HFD-fed mothers, leading to a 40-85% difference (p 0.05), and severe glycogen depletion, lasting until adulthood.Maternal high-fat feeding leads to brain glucose overexposure during fetal development, followed by long-lasting depression in brain glucose metabolism in minipigs. These features may predispose the offspring to develop metabolic-neurodegenerative diseases.