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Your search keyword '"M., Cotellessa"' showing total 5 results
Start Over Author "M., Cotellessa" Journal diabetologia
5 results on '"M., Cotellessa"'

1. A novel hepatocyte nuclear factor-1beta (MODY-5) gene mutation in an Italian family with renal dysfunctions and early-onset diabetes

Author

M. Cotellessa, Barella C, Renata Lorini, Gian Marco Ghiggeri, Carbone I, Francesco Perfumo, Gianluca Caridi, and Carlo Minetti

Subjects
Adult, Male, Endocrinology, Diabetes and Metabolism, MODY 5, Biology, Gene mutation, Kidney, Diabetes mellitus, Internal Medicine, medicine, Humans, Child, Early onset, Hepatocyte Nuclear Factor 1-beta, Genetics, medicine.disease, Kidney Transplantation, Pedigree, DNA-Binding Proteins, Diabetes Mellitus, Type 2, Italy, Hepatocyte Nuclear Factor 1-Beta, Kidney Failure, Chronic, Female, Kidney Diseases, Transcription Factors
Published
2002

3. Permanent diabetes mellitus in the first year of life

Author

Iafusco, D, Stazi, Ma, Cotichini, R, Cotellessa, M, Martinucci, Me, Mazzella, M, Cherubini, V, Barbetti, F, Martinetti, M, Cerutti, Franco, Prisco, F, Early Onset Diabetes Study Group of the Italian Society of Paediatric Endocrinology, Diabetology, Iafusco, Dario, M. A., Stazi, R., Cotichini, M., Cotellessa, M. E., Martinucci, M., Mazzella, V., Cherubini, F., Barbetti, M., Martinetti, F., Cerutti, and F., PRISCO AND THE EARLY ONSET DIABETES STUDY GROUP OF THE ITALIAN SOCIETY OF PAEDIATRIC ENDOCRINOLOGY AND DIABETOLOGY

Subjects
Male, medicine.medical_specialty, non-autoimmune diabetes mellitus, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Birth weight, Population, Gestational Age, Permanent neonatal diabetes, Type I diabetes, HLA protective heterodimers, autoimmune enteropathy, Settore MED/13 - Endocrinologia, Cohort Studies, Islets of Langerhans, Risk Factors, Internal medicine, Diabetes mellitus, Internal Medicine, Medicine, Birth Weight, Humans, Insulin, Age of Onset, education, Autoantibodies, Autoimmune disease, education.field_of_study, business.industry, Infant, Newborn, Infant, Permanent neonatal diabetes mellitus, Infant, Low Birth Weight, medicine.disease, Diabetes Mellitus, Type 1, Italy, Cohort, Immunology, Female, Seasons, Age of onset, business
Abstract

The pathogenesis of permanent diabetes mellitus diagnosed early in life is heterogeneous and, in most cases, not known. We aimed at identifying markers differentiating between non-autoimmune and autoimmune diabetes.The clinical, genetic and epidemiological features of 111 diabetic patients (62 males) who received insulin within 12 months of life were studied.The epidemic curve by age of diabetes onset revealed two subsets of patients at a cutoff of 180 days. In the group with diabetes onset before 180 days ("early onset" permanent diabetes) the analysis of HLA susceptibility heterodimers (available for 21 individuals) showed that 76% had a "protective" HLA genotype for Type I (insulin-dependent) diabetes mellitus as compared to 11.9% (5/42) of the later onset group. Accordingly, "early onset" children were less likely to have autoimmunity markers (4 out of 26 tested) than children with onset after 180 days (13 out 20 tested) (15.4% vs. 65.0%, p0.01). Of note, 19 out of 20 (or the 95%) patients who were born on the island of Sardinia, an Italian region where the incidence of Type I diabetes is six times higher than continental Italy (33/100,000/year vs 5/100,000/year), were included in the later onset group (180 days). Small-for-date birthweight, a possible sign of reduced foetal insulin secretion, was more common in the "early onset" group (OR=9.9, 95%-CI 2.6-38.6).These results, obtained in the largest population-based cohort of diabetic infants hitherto reported, suggest that "early onset" permanent diabetes cases differ from later onset cases and that most of them do not have an autoimmune pathogenesis.

Published
2001

4. Permanent diabetes mellitus in the first year of life.

Author

Iafusco D, Stazi MA, Cotichini R, Cotellessa M, Martinucci ME, Mazzella M, Cherubini V, Barbetti F, Martinetti M, Cerutti F, and Prisco F

Subjects
Autoantibodies blood, Birth Weight, Cohort Studies, Diabetes Mellitus, Type 1 drug therapy, Diabetes Mellitus, Type 1 immunology, Female, Gestational Age, Humans, Infant, Infant, Low Birth Weight, Infant, Newborn, Islets of Langerhans immunology, Italy epidemiology, Male, Risk Factors, Seasons, Age of Onset, Diabetes Mellitus, Type 1 epidemiology, Insulin therapeutic use
Abstract

Aims/hypothesis: The pathogenesis of permanent diabetes mellitus diagnosed early in life is heterogeneous and, in most cases, not known. We aimed at identifying markers differentiating between non-autoimmune and autoimmune diabetes., Methods: The clinical, genetic and epidemiological features of 111 diabetic patients (62 males) who received insulin within 12 months of life were studied., Results: The epidemic curve by age of diabetes onset revealed two subsets of patients at a cutoff of 180 days. In the group with diabetes onset before 180 days ("early onset" permanent diabetes) the analysis of HLA susceptibility heterodimers (available for 21 individuals) showed that 76% had a "protective" HLA genotype for Type I (insulin-dependent) diabetes mellitus as compared to 11.9% (5/42) of the later onset group. Accordingly, "early onset" children were less likely to have autoimmunity markers (4 out of 26 tested) than children with onset after 180 days (13 out 20 tested) (15.4% vs. 65.0%, p<0.01). Of note, 19 out of 20 (or the 95%) patients who were born on the island of Sardinia, an Italian region where the incidence of Type I diabetes is six times higher than continental Italy (33/100,000/year vs 5/100,000/year), were included in the later onset group (>180 days). Small-for-date birthweight, a possible sign of reduced foetal insulin secretion, was more common in the "early onset" group (OR=9.9, 95%-CI 2.6-38.6)., Conclusion/interpretation: These results, obtained in the largest population-based cohort of diabetic infants hitherto reported, suggest that "early onset" permanent diabetes cases differ from later onset cases and that most of them do not have an autoimmune pathogenesis.

Published
2002
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5. A novel hepatocyte nuclear factor-1beta (MODY-5) gene mutation in an Italian family with renal dysfunctions and early-onset diabetes.

Author

Carbone I, Cotellessa M, Barella C, Minetti C, Ghiggeri GM, Caridi G, Perfumo F, and Lorini R

Subjects
Adult, Child, Female, Hepatocyte Nuclear Factor 1-beta, Humans, Italy, Kidney Diseases surgery, Kidney Failure, Chronic genetics, Kidney Transplantation, Male, Pedigree, DNA-Binding Proteins genetics, Diabetes Mellitus, Type 2 genetics, Kidney abnormalities, Kidney Diseases genetics, Transcription Factors genetics
Published
2002
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