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Your search keyword '"Kallio, S."' showing total 5 results
Start Over Author "Kallio, S." Journal diabetologia
5 results on '"Kallio, S."'

1. Natural history of preclinical IDDM in high risk siblings

Author

Knip, M., primary, V�h�salo, P., additional, Karjalainen, J., additional, Lounamaa, R., additional, �kerblom, H. K., additional, Tuomilehto, J., additional, Toivanen, L., additional, Virtala, E., additional, Pitk�niemi, J., additional, Fagerlund, A., additional, Flittner, M., additional, Gustafsson, B., additional, H�ggquist, C., additional, Hakulinen, A., additional, Herva, L., additional, Hiltunen, P., additional, Huhtam�ki, T., additional, Huttunen, N. -P., additional, Huupponen, T., additional, Hyttinen, M., additional, Joki, T., additional, Jokisalo, R., additional, K��r, M. -L., additional, Kallio, S., additional, Kaprio, E. A., additional, Kaski, U., additional, Laine, L., additional, Lappalainen, J., additional, M�enp��, J., additional, M�kel�, A. -L., additional, Niemi, K., additional, Niiranen, A., additional, Nuuja, A., additional, Ojaj�rvi, P., additional, Otonkoski, T., additional, Pihlajam�ki, K., additional, P�ntynen, S., additional, Rajantie, J., additional, Sankala, J., additional, Schumacher, J., additional, Sillanp��, M., additional, St�hlberg, M. -R., additional, Str�hlmann, C. -H., additional, Uotila, T., additional, V�re, M., additional, Varimo, P., additional, Wetterstrand, G., additional, Aro, A., additional, Hurme, H., additional, H�yty, H., additional, Ilonen, J., additional, Leinikki, P., additional, Miettinen, A., additional, R�s�nen, L., additional, Reunanen, A., additional, Savilahti, E., additional, Tuomilehto-Wolf, E., additional, and Virtanen, S. M., additional

Published
1994
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2. Diet, cow's milk protein antibodies and the risk of IDDM in Finnish children

Author

Virtanen, S. M., primary, Saukkonen, T., additional, Savilahti, E., additional, Yl�nen, K., additional, R�s�nen, L., additional, Aro, A., additional, Knip, M., additional, Tuomilehto, J., additional, �kerblom, H. K., additional, Lounamaa, R., additional, Toivanen, L., additional, Kaprio, E. A., additional, Pitk�niemi, J., additional, Virtala, E., additional, Fagerlund, A., additional, Flittner, M. v., additional, Gustafsson, B., additional, H�ggqvist, C., additional, Hakulinen, A., additional, Herva, L., additional, Hiltunen, P., additional, Huhtam�ki, T., additional, Huttunen, N. -P., additional, Huupponen, T., additional, Hyttinen, M., additional, Joki, T., additional, Jokisalo, R., additional, K��r, M. -L., additional, Kallio, S., additional, Kaski, U., additional, Laine, L., additional, Lappalainen, J., additional, M�enp��, J., additional, M�kel�, A. -L., additional, Niemi, K., additional, Niiranen, A., additional, Ojaj�rvi, P., additional, Otonkoski, T., additional, Pihlajam�ki, K., additional, P�ntynen, S., additional, Rajantie, J., additional, Sankala, J., additional, Schumacher, J., additional, Sillanp��, M., additional, St�hlberg, M. -R., additional, Str�hlmann, C. -H., additional, Uotila, T., additional, V�re, M., additional, and Varimo, P., additional

Published
1994
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3. Epidemiology of childhood diabetes mellitus in Finland ? background of a nationwide study of Type 1 (insulin-dependent) diabetes mellitus

Author

Tuomilehto, J., primary, Lounamaa, R., additional, Tuomilehto-Wolf, E., additional, Reunanen, A., additional, Virtala, E., additional, Kaprio, E. A., additional, �kerblom, H. K., additional, Toivanen, L., additional, Fagerlund, A., additional, Flittner, M., additional, Gustafsson, B., additional, Hakulinen, A., additional, Herva, L., additional, Hiltunen, P., additional, Huhtam�ki, T., additional, Huttunen, N. -P., additional, Huupponen, T., additional, Hyttinen, M., additional, H�ggqvist, C., additional, Joki, T., additional, Jokisalo, R., additional, Kallio, S., additional, Kaski, U., additional, Knip, M., additional, K��r, M. -L., additional, Laine, L., additional, Lappalainen, J., additional, M�enp��, J., additional, M�kel�, A. -L., additional, Niemi, K., additional, Niiranen, A., additional, Nuuja, A., additional, Ojaj�rvi, P., additional, Otonkoski, T., additional, Pihlajam�ki, K., additional, P�ntynen, S., additional, Ranjantie, J., additional, Sankala, J., additional, Schumacher, J., additional, Sillanp��, M., additional, Str�hlmann, C. -H., additional, St�hlberg, M. -R., additional, Uotila, T., additional, Varimo, P., additional, Wetterstrand, G., additional, V�re, M., additional, Aro, A., additional, Hurme, H., additional, Hy�ty, H., additional, Ilonen, J., additional, Karjalainen, J., additional, LaPorte, R., additional, Leinikki, P., additional, Miettinen, A., additional, R�s�nen, L., additional, Savilahti, E., additional, and Virtanen, S. M., additional

Published
1992
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4. HLA haplotypes in Type 1 (insulin-dependent) diabetes mellitus: molecular analysis of the HLA-DQ locus.

Author

Tienari, P., Tuomilehto-Wolf, E., Tuomilehto, J., Peltonen, L., Åkerblom, H., Fagerlund, A., Flittner, M., Gustafsson, B., Hakulinen, A., Herva, L., Hiltunen, P., Huhtamäki, T., Huttunen, N., Huupponen, T., Hyttinen, M., Häggqvist, Ch., Joki, T., Jokisalo, R., Kallio, S., and Kaprio, E.

Abstract

In Caucasians the predisposition to Type 1 (insulin-dependent) diabetes mellitus has been shown to associate with HLA-DR3,DQw2 and DR4,DQw8 and with the presence of amino acids other than aspartic acid at position 57 on the HLA-DQβ chain. In Finland the haplotype-specific absolute risk for developing Type 1 diabetes differs between various DR3 and DR4 positive haplotypes. The aim of our present analysis was to find out whether this variation is attributable to polymorphism at the DQ locus. As part of a nationwide prospective study including 757 serologically HLA genotyped families, we determined HLA-DQα and DQβ restriction fragment polymorphisms in 17 selected families with important susceptibility haplotypes. Additionally, the DQA1 alleles were determined from 19 haplotypes using sequence-specific oligonucleotide probes, and the DQB1 second exon was sequenced from nine haplotypes. The DR3 as well as DR4 positive haplotypes frequently found in Type 1 diabetic patients showed no variation at the HLA-DQ locus, and they were DQw2 and DQw8, respectively. The absolute risk for Type 1 diabetes for DR4,DQw8 positive haplotypes A2,Cw4,Bw35,DR4 A3,Cw3,Bw62,DR4, A24,Cw7,Bw39,DR4, A2,Cw3,Bw62, DR4, and A2,Cw1,Bw56,DR4 was 35/100,000, 130/100,000, 166/100,000, 196/100,000, and 218/100,000, respectively. The absolute risks for DR3,DQw2 positive haplotypes A1, Cw7,B8,DR3 and A2,Cw7,B8,DR3 were 68/100,000 and 103/100,000, respectively. These results provide further evidence that not only the polymorphism at the DQ locus but also other genes of the haplotypes contribute to susceptibility to Type 1 diabetes. [ABSTRACT FROM AUTHOR]

Published
1992
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5. Decline of mumps antibodies in Type 1 (insulin-dependent) diabetic children and a plateau in the rising incidence of Type 1 diabetes after introduction of the mumps-measles-rubella vaccine in Finland

Author

Hyöty, H., Hiltunen, M., Reunanen, A., Leinikki, P., Vesikari, T., Lounamaa, R., Tuomilehto, J., Åkerblom, H., Toivanen, L., Kaprio, E., Fagerlund, A., Flittner, M., Gustafsson, B., Häggqvist, C., Hakulinen, A., Herva, L., Hiltunen, P., Huhtamäki, T., Huttunen, N., Huupponen, T., Hyttinen, M., Joki, T., Jokisalo, R., Käär, M., Kallio, S., Kaski, U., Knip, M., Laine, L., Lappalainen, J., Mäenpää, J., Mäkelä, A., Niemi, K., Niiranen, A., Nuuja, A., Ojajärvi, P., Otonkoski, T., Pihlajamäki, K., Pöntynen, S., Rajantie, J., Sankala, J., Schumacher, J., Sillanpää, M., Ståhlberg, M., Stråhlmann, C., Uotila, T., Väre, M., Varimo, P., and Wettenstrand, G.

Abstract

A nationwide mumps-measles-rubella vaccination was introduced in 1982 in Finland to children aged 1.5 to 6 years and since then mumps has virtually disappeared in the country. We investigated whether this rapid epidemiological change had any impact on antibody activity against mumps virus in Type 1 (insulin-dependent) diabetic children or on the incidence of Type 1 diabetes in Finland. Two case-control series were collected before (series I and II) and three series after (series III–V) the introduction of the vaccination. IgA class mumps antibody levels were significantly higher in Type 1 diabetic children than in matched control children in the first two but not in the three later series. IgG class antibody levels were similar in patients and control subjects in the first two series but significantly lower in patients than in control subjects in the three later series. The overall incidence of Type 1 diabetes in 0–14-year-old children increased until 1987 but remained about the same during 1988–1990. In 5–9-year-old children no further increase in Type 1 diabetes was seen since 1985, whereas in 0–4-year-old children the incidence continued to rise until 1990. The results suggest that the elimination of natural mumps by mumps-measles-rubella vaccination may have decreased the risk for Type 1 diabetes in Finland; a possible causal relationship is substantiated by the observed concomitant decrease in mumps antibody levels in diabetic children. However, further studies are required to determine if the vaccine virus, like natural mumps, could trigger the clinical onset of Type 1 diabetes in young children.

Published
1993
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