Search

Your search keyword '"J. C. Dunbar"' showing total 3 results
Start Over Author "J. C. Dunbar" Journal diabetologia
3 results on '"J. C. Dunbar"'

1. The autoregulation of insulin secretion in the isolated pancreatic islets of lean (obOb) and obese-hyperglycemic (obob) mice

Author

J. C. Dunbar, P. P. Foà, L. Loreti, and S. Chen

Subjects
Male, endocrine system, medicine.medical_specialty, Swine, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Mice, Inbred Strains, Cell Separation, Cross Reactions, Biology, Feedback, Islets of Langerhans, Mice, Insulin resistance, Internal medicine, Insulin Secretion, Extracellular fluid, Internal Medicine, medicine, Animals, Insulin, Autoregulation, Obesity, geography, geography.geographical_feature_category, Pancreatic islets, Age Factors, medicine.disease, Islet, Rats, Insulin oscillation, Perfusion, Endocrinology, medicine.anatomical_structure, Hyperglycemia, Female, Insulin Resistance, Extracellular Space, Hyperinsulinism
Abstract

The autoregulation of insulin secretion was studied using perifused and incubated pancreatic islets of normal (obOb) mice and of their obese-hyperglycemic (obob) littermates. Islets secreted more insulin when they were perifused than when they were incubated and insulin was allowed to accumulate in the medium. When rat insulin was added to the incubation medium in the concentration of 250 μU/ml, the secretory activity of the normal islets was suppressed almost completely. The concentration of exogenous insulin required to inhibit the islets of obese mice was higher and increased with the age of the animals, until it reached a value that was 20 to 30 times greater than that found in the circulating blood. Similar concentrations may well exist in the extracellular fluid of the pancreatic islets. It is possible that while insulin resistance of the peripheral tissues may be responsible for the hyperglycemia of the obob mice, the progressive loss of insulin sensitivity of their pancreatic islets and, consequently, of the normal autoregulation of insulin secretion, may play a role in the progressive hyperinsulinism and, hence, of the obesity characteristic of these animals.

Published
1974
Full Text
View/download PDF

2. Seventh Annual Meeting of the European Association for the Study of Diabetes

Author

Bo Hellman, G. C. Palmieri, N. Mihalache, P. Siltanen, G. Bagnariol, W. K. Waldhäusl, M. Javicoli, U. Klör, F.A. Van Assche, M. Rathery, O. Melogli, D. Fedele, E. F. Pfeiffer, G. K. Rastogi, M. Bretán, R. R. de Mowbray, Poul Ebbe Nielsen, A. E. Lambert, Aa. Prange Hansen, Guido Tamburrano, J. C. Sodovez, B. Riveline, J. Canivet, Bartelt Km, S. Efendic, Franco Camanni, J. P. Bali, J. R. Claude, C. Rouiller, B. Schulz, M. Hinz, E. Eschwege, M. M. Mariani, M. Vigas, L. Kammerer, G. Enzi, M. Prud'homme, F. Massi-Benedetti, P. P. Foà, A. Ghidoni, I. M. Burr, L. Niklas, L. Nye, Sotirios Raptis, U. Brinck, B. Meyer, Hamish W. Sutherland, H. Laube, W. R. Drucker, B. Lesobre, H. J. Quabbe, M. A. Page, Åke Lernmark, Raimundo Goberna, M. Muggio, A. van't Laar, R. F. Murphy, Jens F. Rehfeld, Rolf Luft, C. E. Østerby, H. Karmann, K. E. Schröder, Ch. Thum, K. A. Munday, N. Mosora, Y. Kanazawa, D. P. Cameron, C. V. Tompkins, R. E. Levett, P. H. Sönksen, Domenico Andreani, R. D. M. Scott, P. J. Reeds, R. Fellin, A. Loubatières, M. J. Smith, J. Samsel, H. Iwatsuka, A. J. Valleron, S. Persson, K. Pyörälä, Victor Conard, J. M. Warnet, P. Polosa, R. Sparthe, A. Gordon, Y. Abdel Rahman, E. Fusco, Felix P. N. Schennetten, M. C. Srivastava, K. Johansen, D. Wübbens, F. Dauchy, Keith D. Buchanan, J. Marco, W. Teller, W. Poser, J. D. N. Nabarro, M. Rousselet, A. Hasselblatt, G. Rothenbuchner, H. Ørskov, G. M. Molinatti, J. Schönborn, A. Vitelli, A. M. McCarroll, Inge Bert Täljedal, M. Amherdt, R. Knussman, F. A. Gries, L. Orci, Beyer J, F. Jallet, J. Schlichtkrull, Z. Skrabalo, J. Vincze, W. Korp, Schöffling K, Ev. Kriedstein, E. B. Möller, J. Landon, S. Frezzato, H. Wingstrand, F. Massara, G. E. Rosselin, G. J. A. I. Snodgrass, H. L. Fehm, D. Michaelis, S. Le Guilcher, K. Seyer-Hansen, C. Kruger, D. M. Kipnis, J. Mirouze, María L. Villanueva, O. Oelz, P. J. Lefèbvre, V. Duma, Per Westermark, E. Giangrandi, M. R. Turner, H. Bibergeil, G. R. Brisson, J. Birk, T. Mincu, I. M. Baroja, M. R. P. Hall, G. Wick, Patricia Metzger, Werner Oppermann, E. Jutzi, Guido Pozza, P. Jacquet, A. Kopf, J Ostman, N. Conte, R. Fuchs, Theodore Ehrenreich, I. Mincu, Barbara Rudas, A. S. Luyckx, A. E. Renold, A. Schirmann, U. Klemens, R. E. Haist, V. Nuteanu, L. Papoz, R. Spaethe, G. Tohobroutsky, W. Hildmann, V. Gligore, B. Morell, G. Tchobroutsky, Willy Malaisse, J. Sterne, G. Löffler, N. S. Track, E. B. Marliss, EskoA. Nikkilä, C. R. C. Heard, Tr. Baciu, F. Fallucca, E. Krug, J. Trap-Jensen, Isabel Valverde, Rafael A. Camerini-Davalos, S. Klahr, L. Stimmler, C. Rosak, M. Motocou, K. W. Taylor, H. Otto, O. Wieland, K. Lundbak, Th. Koschinsky, R. Assan, E. Cerasi, M. Toeller, S. Triggs, W. Stauffacher, Haupt E, R. J. Dash, C. Scandellari, E. R. Froesch, F. J. Woodroffe, L. Balant, M. Verry, M. Lunetta, A. Tiengo, D. G. Parry, L. Weiss, M. Kikuchi, Uwe Panten, G. C. Viberti, B. Blondel, J. D. Teale, J. C. Dunbar, N. S. Bricker, C. E. Ruth, M. K. Sinha, W. Braun, M.R. Taskinen, D. H. Williamson, U. Loos, O. Steingaszner, Giovanni Federspil, L. Herberg, S. Georgescu, R. Fussgänger, J. Hewitt, A. L. Bergström, S. Levin Nielsen, H. Schatz, E. Lehtovirta, Jurgen Steinke, I. Lozano, F. Sodovez-Goffaux, D. R. Langslow, E. Speich, I. Neumann, G. Menzinger, A. Tinant, S. Munkgaard Rasmussen, Janove Sehlin, C. Dumitrescu, N. Katsilambros, A. Tognetti, Ligia Simionesco, C. Oliver, C. E. Mogensen, A. E. Pappalettera, P. Vague, K. Sträub, L. Motta, J. Vague, A. Orsetti, Mme A. Serre, B. M. Freeman, A. Trisotto, R. Korec, M. Diaz-Fierros, F. Stadil, S. Campeanu, J. Sabin, H. P. T. Ammon, P. Mialhe, F. Legros, C. Rogister, R. Schröder, V. Maier, Risto Pelkonen, F. Scaroina, M. Parvulescu, and K. E. Schenk

Subjects
medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Association (object-oriented programming), Family medicine, Ophthalmology, Diabetes mellitus, Internal Medicine, medicine, Human physiology, business, medicine.disease
Published
1972
Full Text
View/download PDF

3. An inhibitory effect of tolbutamide and glibenclamide (glyburide) on the pancreatic islets of normal animals

Author

J. C. Dunbar and P. P. Foà

Subjects
Blood Glucose, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Tolbutamide, Glibenclamide, Islets of Langerhans, In vivo, Leucine, Internal medicine, Glyburide, Internal Medicine, medicine, Animals, Insulin, Carbon Radioisotopes, Saline, business.industry, Pancreatic islets, Sulfonylurea, Endocrinology, medicine.anatomical_structure, Glucose, Female, business, Pancreas, medicine.drug
Abstract

Tolbutamide and glibenclamide (glyburide) were administered to normal hamsters, mice or rats in daily doses proportional to their body weight and equivalent to those used in human therapy. The animals were sacrificed after 6 to 8 weeks of treatment. Pieces of pancreas or isolated pancreatic islets were incubated or perifused in a medium containing glucose or tolbutamide, with or without Ieucine-114C or glucose-U-14C. The results indicate that the B cells of sulfonylurea treated animals synthesized and released less insulin and oxidized less glucose than those of insulin or saline treated controls. Accordingly, at least in the glibenclamide treated animals, the tolerance for glucose and the insulinogenic response to a glucose load in vivo were suppressed. Although insular function tended to return, to normal after treatment was discontinued, the results reported in this paper do not support the generally accepted view that the lasting therapeutic effectiveness of the sulfonylureas is due to a beta-cytotrophic action.

Published
1974

Catalog

Books, media, physical & digital resources
See catalog results