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Your search keyword '"BOZZETTO, LUTGARDA"' showing total 5 results
Start Over Author "BOZZETTO, LUTGARDA" Journal diabetologia
5 results on '"BOZZETTO, LUTGARDA"'

2. Dietary determinants of postprandial blood glucose control in adults with type 1 diabetes on a hybrid closed-loop system.

Author

Vetrani, Claudia, Calabrese, Ilaria, Cavagnuolo, Luisa, Pacella, Daniela, Napolano, Elsa, Di Rienzo, Silvia, Riccardi, Gabriele, Rivellese, Angela A., Annuzzi, Giovanni, and Bozzetto, Lutgarda

Abstract

Aims/hypothesis: The aim of this work was to assess the relationship between meal nutrients and postprandial blood glucose response (PGR) in individuals with type 1 diabetes on a hybrid closed-loop system (HCLS). Methods: The dietary composition of 1264 meals (398 breakfasts, 441 lunches and 425 dinners) was assessed by 7-day food records completed by 25 individuals with type 1 diabetes on HCLSs (12 men/13 women, mean ± SD age 40 ± 12 years, mean ± SD HbA1c 51 ± 10 mmol/mol [6.9 ± 0.2%]). For each meal, PGR (continuous glucose monitoring metrics, glucose incremental AUCs) and insulin doses (pre-meal boluses, post-meal microboluses automatically delivered by the pump and adjustment boluses) over 6 h were evaluated. Results: Breakfast, lunch and dinner significantly differed with respect to energy and nutrient intake and insulin doses. The blood glucose postprandial profile showed an earlier peak after breakfast and a slow increase until 4 h after lunch and dinner (p < 0.001). Mean ± SD postprandial time in range (TIR) was better at breakfast (79.3 ± 22.2%) than at lunch (71.3 ± 23.9%) or dinner (70.0 ± 25.9%) (p < 0.001). Significant negative predictors of TIR at breakfast were total energy intake, per cent intake of total protein and monounsaturated fatty acids, glycaemic load and absolute amounts of cholesterol, carbohydrates and simple sugars consumed (p < 0.05 for all). No significant predictors were detected for TIR at lunch. For TIR at dinner, a significant positive predictor was the per cent intake of plant proteins, while negative predictors were glycaemic load and intake amounts of simple sugars and carbohydrate (p < 0.05 for all). Conclusions/interpretation: This study shows that nutritional factors other than the amount of carbohydrate significantly influence postprandial blood glucose control. These nutritional determinants vary between breakfast, lunch and dinner, with differing effects on postprandial blood glucose profile and insulin requirements, thus remaining a challenge to HCLSs. [ABSTRACT FROM AUTHOR]

Published
2022
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4. Polyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: a controlled randomised intervention trial

Author

Bozzetto, Lutgarda, primary, Annuzzi, Giovanni, additional, Pacini, Giovanni, additional, Costabile, Giuseppina, additional, Vetrani, Claudia, additional, Vitale, Marilena, additional, Griffo, Ettore, additional, Giacco, Angela, additional, De Natale, Claudia, additional, Cocozza, Sara, additional, Della Pepa, Giuseppe, additional, Tura, Andrea, additional, Riccardi, Gabriele, additional, and Rivellese, Angela A., additional

Published
2015
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5. Polyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: a controlled randomised intervention trial

Author

Claudia Vetrani, Angela A. Rivellese, Andrea Tura, Giuseppina Costabile, A. Giacco, S. Cocozza, Gabriele Riccardi, Giovanni Pacini, Giovanni Annuzzi, Lutgarda Bozzetto, Marilena Vitale, E. Griffo, Giuseppe Della Pepa, Claudia De Natale, Bozzetto, Lutgarda, Annuzzi, Giovanni, Pacini, Giovanni, Costabile, Giuseppina, Vetrani, Claudia, Vitale, Marilena, Griffo, Ettore, Giacco, Angela, DE NATALE, Claudia, Cocozza, Sara, DELLA PEPA, Giuseppe, Tura, Andrea, Riccardi, Gabriele, and Rivellese, ANGELA ALBAROSA

Subjects
Adult, Blood Glucose, Male, medicine.medical_specialty, Diabetes risk, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Insulin resistance, Metabolic Diseases, Glucagon-Like Peptide 1, Insulin-Secreting Cells, Internal medicine, Diabetes mellitus, Fatty Acids, Omega-3, Internal Medicine, Humans, Insulin, Medicine, Outpatient clinic, Obesity, polyphenols, glucose metabolism, Aged, Glucose tolerance test, medicine.diagnostic_test, business.industry, Polyphenols, Glucose Tolerance Test, Middle Aged, medicine.disease, Diet, Glucose, Endocrinology, Postprandial, Cardiovascular Diseases, Patient Compliance, Female, Insulin Resistance, Waist Circumference, Metabolic syndrome, business
Abstract

Dietary polyphenols and long chain n-3 polyunsaturated fatty acids (LCn3) are associated with lower cardiovascular risk. This may relate to their influence on glucose metabolism and diabetes risk. We evaluated the effects of diets naturally rich in polyphenols and/or LCn3 of marine origin on glucose metabolism in people at high cardiometabolic risk. According to a 2 × 2 factorial design, individuals with high waist circumference and at least one more component of the metabolic syndrome were recruited at the obesity outpatient clinic. Eighty-six participants were randomly assigned by MINIM software to an isoenergetic diet: (1) control, low in LCn3 and polyphenol (analysed n = 20); (2) rich in LCn3 (n = 19); (3) rich in polyphenols (n = 19); or (4) rich in LCn3 and polyphenols (n = 19). The assigned diets were known for the participants and blinded for people doing measurements. Before and after the 8 week intervention, participants underwent a 3 h OGTT and a test meal with a similar composition as the assigned diet for the evaluation of plasma glucose, insulin and glucagon-like peptide 1 (GLP-1) concentrations, and indices of insulin sensitivity and beta cell function. During OGTT, polyphenols significantly reduced plasma glucose total AUC (p = 0.038) and increased early insulin secretion (p = 0.048), while LCn3 significantly reduced beta cell function (p = 0.031) (two-factor ANOVA). Moreover, polyphenols improved post-challenge oral glucose insulin sensitivity (OGIS; p = 0.05 vs control diet by post hoc ANOVA). At test meal, LCn3 significantly reduced GLP-1 total postprandial AUC (p

Published
2015

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