1. The relationship between glycated hemoglobin and polymorphonuclear leukocyte leukotriene B4 release in people with diabetes mellitus
- Author
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S. Sanguigni, C. Danese, C. Parlapiano, M. Marangi, T. Giovanniello, E. Campana, E. Zavattaro, and P. Pantone
- Subjects
Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Leukotriene B4 ,Neutrophils ,Endocrinology, Diabetes and Metabolism ,In Vitro Techniques ,chemistry.chemical_compound ,Endocrinology ,Reference Values ,Immunopathology ,Diabetes mellitus ,Internal medicine ,Blood plasma ,Internal Medicine ,medicine ,Humans ,Calcimycin ,Aged ,Glycated Hemoglobin ,Type 1 diabetes ,business.industry ,Type 2 Diabetes Mellitus ,General Medicine ,Middle Aged ,medicine.disease ,Pathophysiology ,Diabetes Mellitus, Type 1 ,chemistry ,Diabetes Mellitus, Type 2 ,Regression Analysis ,Female ,Glycated hemoglobin ,business - Abstract
In order to evaluate polymorphonuclear leukocyte (PMN) activity in diabetes mellitus, leukotriene B4 (LTB4) levels were measured in sixty patients, 31 affected with Type 1 diabetes mellitus and 29 affected with Type 2 diabetes mellitus. The LTB4 levels (12.1+/-0.2 pg/100 microl) in diabetic patients were higher compared to those of the control group (7.9+/-0.1 pg/100 microl) (P < 0.001), and remained significantly higher (P < 0.001) (12.8+/-0.2 pg/100 microl) than in the control group (11.0+/-0.2 pg/100 microl) after stimulation with calcium ionophore. A significant and positive correlation between glycated hemoglobin and LTB4 was demonstrated (P < 0.001, r = 0.80). This study demonstrates that in diabetic patients there is a PMN activation and that this activation is correlated to glycated hemoglobin level.
- Published
- 1999