1. 13C/12C breath test ratio after the ingestion of a meal naturally enriched with (13C)carbohydrates is a surrogate marker of insulin resistance and insulin sensitivity in children and adolescents with Type 1 Diabetes
- Author
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Elena Fornari, Marco Marigliano, Francesca Tomasselli, Massimiliano Corradi, Mara Tommasi, Claudio Maffeis, Yves Schutz, Francesca Olivieri, Anita Morandi, and Claudia Piona
- Subjects
medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Carbohydrate metabolism ,Adolescents ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Insulin resistance ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,Ingestion ,030212 general & internal medicine ,Children ,Breath test ,Type 1 diabetes ,medicine.diagnostic_test ,business.industry ,Area under the curve ,(13)C/(12)C ratio ,General Medicine ,Insulin sensitivity ,medicine.disease ,Glucose breath test ,Postprandial ,Insulin resistance - carbohydrate oxidation ,business - Abstract
Aims To test the hypotheses that exogenous carbohydrate oxidation affects postprandial glycaemic profiles and 13C/12C breath test could be used for estimating insulin resistance (IR) and insulin sensitivity (IS) in youths with Type 1 Diabetes (T1D). Methods Non-randomized, cross-sectional study for repeated measures; fifteen youths (11–15 years) with T1D were enrolled. Respiratory exchanges were measured by indirect calorimetry after the ingestion of a mixed meal [13% protein, 29% fat, 58% carbohydrate (CHO; naturally enriched with [13C]carbohydrates)]. Total and exogenous CHOs oxidation was calculated by indirect calorimetry and 13C/12C breath test. IR and IS were calculated using estimated Glucose Disposal Rate (eGDR) and Insulin Sensitivity Score (ISS). Results The blood glucose Area Under the Curve (BG-AUC) was significantly associated with the amount of exogenous CHOs oxidized (r = −0.67, p Conclusions Assessing the capacity to oxidize exogenous CHOs (estimated by the differential of 13C/12C enrichment in the expired air at the breath test) could be used as a non-invasive surrogate marker of IR and IS in youths with T1D.
- Published
- 2020
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