1. Myocardial perfusion at rest in patients with Diabetes Mellitus Type 1 compared with healthy controls assessed with Multi Detector Computed Tomography.
- Author
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Byrne, Christina, Jensen, Tonny, Hjortkjær, Henrik Øder, Mogensen, U.M., Kuhl, J.T., Fuchs, Andreas, Hilsted, Jannik, Nordestgaard, Børge G., Køber, Lars, and Kofoed, K.F.
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MYOCARDIAL perfusion imaging , *REST , *TYPE 1 diabetes , *COMPUTED tomography , *LEFT heart ventricle , *LOW density lipoproteins - Abstract
Aim Type 1 diabetes mellitus (T1DM) is associated with an increased risk of ischemic heart disease (IHD). The relative contribution of structural and functional abnormalities of the coronary circulation determining clinically manifested IHD remains unknown. The aim of this study was to assess potential differences in myocardial perfusion at rest and coronary atherosclerosis between asymptomatic T1DM patients and healthy controls. Methods Left ventricular (LV) myocardial perfusion at rest measured as LV myocardial Attenuation Density/LV blood pool Attenuation Density (Myo AD -ratio) and coronary artery atherosclerosis were evaluated with 320-multidetector computed tomography angiography in 57 asymptomatic T1DM patients and 114 sex and age matched controls. Results In both groups median age was 53 years (p5,p95: 42,67) and 59.6% were men. Median duration of diabetes in the T1DM group was 35 years (p5,p95: 17,49). Median coronary calcium score was higher in T1DM patients (51 vs. 2, p = 0.037) compared with controls. However, a similar frequency of >50% stenosis in one or more coronary arteries was found in T1DM patients and controls (18% vs. 14%, p = 0.49). LV myocardial perfusion at rest (Myo AD -ratio) was 18% higher in T1DM patients than controls (0.13 vs. 0.11, p < 0.0001). This difference was noted throughout all the LV myocardial segments. In a multiple regression analysis including diabetes, sex, age, cardiovascular risk factors, heart rate, calcium score and coronary stenosis >50%, Myo AD -ratio remained significantly higher in T1DM patients ( p = 0.0001). Conclusions LV myocardial perfusion at rest is higher in T1DM patients compared with controls independent of coronary atherosclerosis and cardiovascular risk factors. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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