11 results on '"Toth EL"'
Search Results
2. Generalizability and persistence of a multifaceted intervention for improving quality of care for rural patients with type 2 diabetes.
- Author
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Johnson JA, Eurich DT, Toth EL, Lewanczuk RZ, Lee TK, and Majumdar SR
- Subjects
- Aged, Alberta, Blood Pressure, Body Mass Index, Cholesterol blood, Diabetic Angiopathies epidemiology, Female, Glycated Hemoglobin analysis, Humans, Male, Middle Aged, Quality Assurance, Health Care, Socioeconomic Factors, Diabetes Mellitus, Type 2 therapy, Diabetic Angiopathies prevention & control, Rural Population
- Abstract
Objective: Most quality improvement efforts for type 2 diabetes have neglected cardiovascular risk factors and are limited by a lack of information about generalizability across settings or persistence of effect over time., Research Design and Methods: We previously reported 6-month results of a controlled study of an intervention that improved cardiovascular risk factors for rural patients with type 2 diabetes. We subsequently provided the identical intervention to the control region after the main study was completed. The primary outcome was 10% improvement in systolic blood pressure, total cholesterol, or HbA(1c). We compared the previously reported 6-month effect of the original intervention with the effect of the crossed-over intervention to the former control region and remeasured outcomes in the original intervention region 12 months later., Results: Our analysis included 200 original intervention and 181 crossed-over intervention subjects. The age of the population was 62.4 +/- 12.4 years (mean +/- SD), and 54.3% were women. A similar proportion of patients in the crossed-over intervention group achieved improvement in the primary composite outcome compared with the original intervention group (38 vs. 44%, respectively; P = 0.29). In adjusted analyses, we observed less improvement in blood pressure (adjusted odds ratio 0.40 [95% CI 0.17-0.75]) but greater improvements in total cholesterol (1.86 [0.93-3.7]) with the crossed-over intervention compared with the original intervention. We observed sustained improvements in total cholesterol and HbA(1c) levels in the original intervention group, whereas previous large gains in control of blood pressure diminished over time., Conclusions: We found that our intervention was generalizable across settings, and its effect persisted over time. Nevertheless, without ongoing intervention or reinforcement, we noted some loss of the original benefits that had accrued. Future translational work should incorporate interventions such as ours into ongoing systems of rural care.
- Published
- 2005
- Full Text
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3. Improvements in patient-reported outcomes associated with an intervention to enhance quality of care for rural patients with type 2 diabetes: results of a controlled trial.
- Author
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Maddigan SL, Majumdar SR, Guirguis LM, Lewanczuk RZ, Lee TK, Toth EL, and Johnson JA
- Subjects
- Alberta, Female, Humans, Male, Middle Aged, Patient Care Team, Quality Assurance, Health Care, Rural Health Services standards, Socioeconomic Factors, Treatment Outcome, Diabetes Mellitus, Type 2 therapy, Rural Population
- Abstract
Objective: The aim of this study was to examine patient-reported outcomes in a controlled trial of a multifaceted provider-level intervention to improve quality of care for rural patients with type 2 diabetes., Research Design and Methods: We conducted a before/after intervention study with concurrent controls in two rural regions in Alberta, Canada. The intervention consisted of six monthly visits by a multidisciplinary health care team and was primarily directed at primary care providers. Clinical and patient-reported outcomes were assessed after 6 months. Patient-reported outcomes included changes in health-related quality of life (Health Utilities Index Mark 3 [HUI3]), satisfaction with care, lifestyle (Diabetes Lifestyle Form), and adherence to self-care activities. Analysis of covariance was used to assess differences over time between the control and intervention regions., Results: A total of 200 intervention and 172 control subjects were included in this analysis. After adjusting for important clinical and demographic differences, a statistically significant and clinically important improvement in the overall HUI3 score was seen at the 6-month follow-up in the intervention region (0.06 [95% CI 0.02-0.10]) compared with the control region (0.01 [-0.04 to 0.04]) (P = 0.03 for the difference between groups). Satisfaction with general medical care (P < 0.001 between groups) and diabetes care (P < 0.001 between groups) increased among patients in the intervention region compared with the control region. Self-efficacy, attitudes, and beliefs about diabetes control all increased in the intervention region when compared with the control region, but adherence to self-care activities did not., Conclusions: A provider-level intervention directed at improving quality of clinical care for patients with type 2 diabetes also had a favorable impact on overall health-related quality of life, satisfaction with care, and other humanistic outcomes.
- Published
- 2004
- Full Text
- View/download PDF
4. Comparison of the [13C]glucose breath test to the hyperinsulinemic-euglycemic clamp when determining insulin resistance.
- Author
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Lewanczuk RZ, Paty BW, and Toth EL
- Subjects
- Adult, Analysis of Variance, Carbon Isotopes, Diabetes Mellitus, Type 2 blood, Glucose Clamp Technique, Humans, Hyperinsulinism, Reference Values, Regression Analysis, Reproducibility of Results, Blood Glucose metabolism, Breath Tests methods, Glucose analysis, Insulin Resistance physiology
- Abstract
Objective: With increasing emphasis on the recognition of the metabolic syndrome and early type 2 diabetes, a clinically useful measure of insulin resistance is desirable. The purpose of this study was to evaluate whether an index of glucose metabolism, as measured by (13)CO(2) generation from ingested [(13)C]glucose, would correlate with indexes from the hyperinsulinemic-euglycemic clamp., Research Design and Methods: A total of 26 subjects with varying degrees of insulin sensitivity underwent both the [(13)C]glucose breath test and the hyperinsulinemic-euglycemic clamp. Results from the [(13)C]glucose breath test were compared with measures of insulin sensitivity from the glucose clamp as well as with other commonly used indexes of insulin sensitivity., Results: There was a strong correlation between the [(13)C]glucose breath test result and the glucose disposal rate (r = 0.69, P < 0.0001) and insulin sensitivity index (r = 0.69, P < 0.0001) from the insulin clamp. The magnitude of these correlations compared favorably with QUICKI and were superior to the homeostasis model assessment., Conclusions: The [(13)C]glucose breath test may provide a useful noninvasive assessment of insulin sensitivity.
- Published
- 2004
- Full Text
- View/download PDF
5. Controlled trial of a multifaceted intervention for improving quality of care for rural patients with type 2 diabetes.
- Author
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Majumdar SR, Guirguis LM, Toth EL, Lewanczuk RZ, Lee TK, and Johnson JA
- Subjects
- Aged, Alberta, Community-Institutional Relations, Female, Humans, Male, Middle Aged, Program Evaluation, Prospective Studies, Rural Health Services organization & administration, Rural Population, Diabetes Mellitus, Type 2 therapy, Outcome Assessment, Health Care, Quality of Health Care, Rural Health Services standards
- Abstract
Objective: Despite good evidence and clinical practice guidelines, studies document that treatment of type 2 diabetes is less than optimal. Lack of resources or limited access may put patients in rural communities at particular risk for suboptimal care., Research Design and Methods: We conducted a prospective, before/after study with concurrent controls to assess the effectiveness of a multidisciplinary diabetes outreach service (intervention) for improving the quality of care for rural patients with type 2 diabetes. Our intervention consisted of six monthly visits by a traveling team of specialist physicians, nurses, dieticians, and a pharmacist. The core of this service was specialist-to-rural primary care physician academic group detailing. Two comparable regions in Northern Alberta were randomly allocated to control or intervention. Data were collected before and 6 months after intervention in a representative volunteer sample. The primary outcome was a 10% improvement in any one of the following: blood pressure, total cholesterol, or HbA(1c)., Results: Our analysis included 200 intervention and 179 control subjects; 14 subjects were at all three primary outcome targets at baseline. The intervention was associated with a trend toward improvement in primary outcome at 6 months (44% intervention vs. 37% control; odds ratio 1.32, 95% CI 0.87-1.99). The intervention was associated with a significant improvement in blood pressure (42% intervention vs. 25% control, P = 0.004); however, there were only small, nonsignificant changes in cholesterol or HbA(1c). The intervention was associated with a significant increase in satisfaction with diabetes care. Multivariate adjustment for baseline differences between intervention and control subjects did not affect any of the main results., Conclusions: A diabetes outreach service has the potential to improve the quality of diabetes care for rural patients. Future studies need to involve longer timelines and larger sample sizes.
- Published
- 2003
- Full Text
- View/download PDF
6. Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes.
- Author
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Johnson JA, Majumdar SR, Simpson SH, and Toth EL
- Subjects
- Aged, Cause of Death, Cohort Studies, Databases, Factual, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Hypoglycemic Agents adverse effects, Male, Metformin adverse effects, Middle Aged, Saskatchewan epidemiology, Sulfonylurea Compounds adverse effects, Time Factors, Diabetes Mellitus, Type 2 drug therapy, Diabetes Mellitus, Type 2 mortality, Hypoglycemic Agents therapeutic use, Metformin therapeutic use, Sulfonylurea Compounds therapeutic use
- Abstract
Objective: The aim of this study was to examine the relationship between use of metformin and sulfonylurea and mortality in new users of these agents., Research Design and Methods: Saskatchewan Health databases were used to examine population-based mortality rates for new users of oral antidiabetic agents. Individuals with prescriptions for sulfonylurea or metformin in 1991-1996 and no use in the year prior were identified as new users. Prescription records were prospectively followed for 1-9 years; subjects with any insulin use were excluded. Causes of death were identified based on ICD-9 codes in an electronic vital statistics database. Multivariate logistic regression and survival analyses were used to assess the differences in mortality between drug cohorts, after adjusting for potential confounding variables., Results: The total study sample comprised 12,272 new users of oral antidiabetic agents; the average length of follow-up was 5.1 (SD 2.2) years. In subjects with at least 1 year of drug exposure and no insulin use, mortality rates were 750/3,033 (24.7%) for those receiving sulfonylurea monotherapy, 159/1,150 (13.8%) for those receiving metformin monotherapy, and 635/4,683 (13.6%) for those receiving combination therapy over an average 5.1 (SD 2.2) years of follow-up. The adjusted odds ratio (OR) for all-cause mortality for metformin monotherapy was 0.60 (95% CI 0.49-0.74) compared with sulfonylurea monotherapy. Sulfonylurea plus metformin combination therapy was also associated with reduced all-cause mortality (OR 0.66, 95% CI 0.58-0.75). Reduced cardiovascular-related mortality rates were also observed in metformin users compared with sulfonylurea monotherapy users., Conclusions: Metformin therapy, alone or in combination with sulfonylurea, was associated with reduced all-cause and cardiovascular mortality compared with sulfonylurea monotherapy among new users of these agents.
- Published
- 2002
- Full Text
- View/download PDF
7. High incidence of IDDM over 6 years in Edmonton, Alberta, Canada.
- Author
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Toth EL, Lee KC, Couch RM, and Martin LF
- Subjects
- Adolescent, Age Distribution, Alberta epidemiology, Child, Child, Preschool, Female, Humans, Incidence, Infant, Male, Seasons, Sex Distribution, Time Factors, Diabetes Mellitus, Type 1 epidemiology
- Abstract
Objective: To determine the incidence of IDDM among children 0-14 years of age in Edmonton, Alberta, between 1990 and 1995 by means of a population-based registry., Research Design and Methods: Children < 15 years of age diagnosed with IDDM between January 1990 and December 1995 were registered according to criteria of the World Health Organization (WHO) Multinational Project for Childhood Diabetes. The primary source of case ascertainment consisted of office records of pediatricians and endocrinologists. The secondary source consisted of inpatient records from the main city hospitals., Results: Between 1990 and 1995, 211 IDDM patients < 15 years of age were detected by the two sources. All but 15 of them were of European ancestry. The ascertainment-corrected incidence rates of this ethnic group (constituting 77% of the population) for the 6 years were 38.6, 23.5, 23.3, 24.2, 22.0, and 24.3 per 100,000, respectively, with case ascertainment rates of 75-95%. The age-adjusted rate over the 6-year period was 25.7 per 100,000 with a case ascertainment rate of 84.3%. No sex difference was observed. The highest incidence occurred in the 10- to 14-year-old age-group, and more cases were detected between January and March than at other periods in the year., Conclusions: The incidence of IDDM among the European-derived population in Edmonton between 1990 and 1995 is the highest rate over a 6-year period to be reported in North America, comparable to that in Prince Edward Island, Canada, and to the highest rates in the world.
- Published
- 1997
- Full Text
- View/download PDF
8. Recurrent infection of continuous subcutaneous insulin infusion sites with Mycobacterium fortuitum.
- Author
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Toth EL, Boychuk LR, and Kirkland PA
- Subjects
- Anti-Bacterial Agents therapeutic use, Blood Glucose metabolism, Cefoxitin therapeutic use, Ciprofloxacin therapeutic use, Drug Therapy, Combination therapeutic use, Glycated Hemoglobin analysis, Humans, Insulin administration & dosage, Minocycline adverse effects, Minocycline therapeutic use, Mycobacterium Infections drug therapy, Mycobacterium Infections surgery, Recurrence, Diabetes Mellitus, Type 1 drug therapy, Injections, Subcutaneous adverse effects, Insulin therapeutic use, Mycobacterium Infections etiology
- Published
- 1995
- Full Text
- View/download PDF
9. Factitious diabetes mellitus and spontaneous hypoglycemia. Consequences of unrecognized Munchausen syndrome by proxy.
- Author
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Kovacs CS and Toth EL
- Subjects
- Adolescent, Blood Glucose analysis, Blood Glucose Self-Monitoring, Humans, Male, Diabetes Mellitus, Diet, Diabetic, Fathers, Hypoglycemia, Munchausen Syndrome by Proxy diagnosis
- Abstract
Objective: To increase health-care professionals' awareness and knowledge of factitious illness by proxy, or Munchausen syndrome by proxy, in relatives of diabetic patients., Research Design and Methods: A case report is described of a 14-yr-old male who has a 6-yr history of diet-controlled diabetes mellitus, and a 6-mo history of reported spontaneous hypoglycemia., Results: Neither diabetes nor spontaneous hypoglycemia was present in this child on objective testing. The child was subjected to inappropriate use of a strict diabetic diet and daily glucometer measurements for at least 8 yr. The father had convinced his son and health-care professionals of these diagnoses, in spite of evidence of the contrary., Conclusions: When confronted with history and clinical findings that contradict laboratory findings, health-care professionals should have a high index of suspicion for factitious illness and should pursue it aggressively with the help of legal services.
- Published
- 1993
- Full Text
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10. Brain wave on the witness stand.
- Author
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Toth EL
- Subjects
- Canada, Epinephrine metabolism, Expert Testimony, Humans, Hypoglycemia physiopathology, Insulin therapeutic use, Male, Cognition Disorders, Confusion, Diabetes Mellitus, Type 1 drug therapy, Hypoglycemia psychology, Insulin adverse effects, Theft
- Published
- 1990
- Full Text
- View/download PDF
11. Psychological adjustment to diabetes: a cautious interpretation.
- Author
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Toth EL
- Subjects
- Child, Humans, Adaptation, Psychological, Diabetes Mellitus, Type 1 psychology
- Published
- 1987
- Full Text
- View/download PDF
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