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1. Comment on: Chakera et al. Antenatal Diagnosis of Fetal Genotype Determines if Maternal Hyperglycemia due to a Glucokinase Mutation Requires Treatment. Diabetes Care 2012;35:1832–1834

Author

Dario Iafusco, Teresa Sena, Edoardo Tartaglia, Brunella Giugliano, Angelo Perrotta, Pasquale Mastrantonio, and Piero Giuliano

Subjects
medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Birth weight, medicine.medical_treatment, Female, Glucokinase, Humans, Hyperglycemia, Pregnancy, Prenatal Diagnosis, Internal Medicine, Advanced and Specialized Nursing, Prenatal diagnosis, Endocrinology, Online Letters: Comments and responses, Internal medicine, Diabetes mellitus, medicine, Genetic testing, medicine.diagnostic_test, business.industry, Obstetrics, Insulin, medicine.disease, Diabetes and Metabolism, Gestational diabetes, business
Abstract

We have read with great interest the article by Chakera et al. (1) describing two cases of gestational diabetes mellitus due to a mutation in the glucokinase ( GCK ) gene. As a result of antenatal genetic testing, the fetuses had inherited the GCK mutation. Neither fetuses nor mothers received insulin treatment for established maternal hyperglycemia in the third trimester, and the children had a normal birth weight and no metabolic complications. The data of Chakera et al. seemed to confirm our published theory; therefore, a nonmutated GCK child from a maturity-onset diabetes of the young type 2 (MODY2+) mother may have the same complications as a diabetic mother's son and, in this …

Published
2012
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