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Diabetes mellitus (DM) is the 7th leading cause of death in the U.S. in 2015. According to Center of Disease Control (CDC), prevalence of DM has increased in recent years affecting 9.4% of U.S. population and 12.5% of New York City (NYC) population in 2015. Increased DM prevalence is a worldwide trend associated with increasing age of the population. Aim: To determine prevalence and severity of diabetes/prediabetics in NYC Chinese population in comparison with those of non-Chinese patients. Methods: We obtained and analyze HMO A1C data of 276,854 Chinese (age 18-98 with median of 51 years, 55% female, 45% male, representing the largest population studies) and non-Chinese sampling population in NYC from January 2015 to October 2018 using BioReference Lab. Patients (57,612 Chinese, 49,548 non-Chinese) classified as prediabetics with A1C between 5.7-6.4% upon initial A1C test had follow-up test after management according to CDC Prediabetic management protocol. Results: Of 197,487 Chinese who had A1C test indicated prevalence of 18.5% diabetes, 45.6% of prediabetic and 35.6% nondiabetics. The male group had a higher incidence of diabetes than females (21% vs. 16.5%). Among 1,341,054 non-Chinese clients, there were 51.6% nondiabetics, 31.4% prediabetics and 18.0% diabetes. The severity of diabetes with respect to A1C data in 36,596 Chinese were 6.5-7.4, 57%; 7.5-9.0, 27%; >9.0, 16% whereas in 241,180 non-Chinese they were 44%, 29% and 28%, respectively. Among Chinese prediabetics, 30% reversed to nondiabetics and 5.7% progressed to diabetic categories, whereas among non-Chinese prediabetics, 25.8% reverse to nondiabetics and 11.1% progressed to diabetics during the study time. Conclusion: Prevalence of diabetes in NYC population is higher than that found in 2015. More severe diabetes with higher A1C levels was found in non-Chinese than Chinese patients. The NYC Chinese had higher incidence of prediabetics but had better management outcome than non-Chinese community. Disclosure G. Liu: None. J.D. George: None. J.W. Sharp: None. A. Hu: None. T. Chang: None.

Diabetes mellitus (DM) and prediabetes incidence have increased in the U.S. in recent years. In our center we have observed higher prevalence of diabetes/prediabetes in NYC Chinese-Americans than the general population. Diabetes patients are often associated with cardiovascular disease and chronic kidney disease (CKD). Aim: To determine the relationship between diabetes status and CKD status in NYC Chinese population compared to the general population so that proper medical management can be achieved. Method: Using A1C test to determine the diabetes status, with A1C value of 6.5 as diabetics. Estimated glomerular filtration rate (eGFR) were determined and values Results: In both populations the A1C levels tended to increase with increasing age, whereas their mean eGFR tended to decrease with age. The CKD prevalence was 8.9% in Chinese and 9.5% in non-Chinese. In 18-64 years groups CKD was 2.4% in Chinese and 2.7% in non-Chinese, whereas in ≥65 years group they were 29% in Chinese and 25.6% in non-Chinese. When A1C and eGFR were reviewed together, CKD prevalence was 3.1% of nondiabetics, 10.3% of prediabetics, 22.6% of A1C 6.5-6.9 DM, 24.1% of A1C 7.0-8.0 DM, 29.6% of A1C 8.1-8.9 DM and 27.6% of A1C >9.0 in Chinese population. In non-Chinese population, the CKD prevalence was 5.3%, 13.2%, 21.1%, 23.5%, 23.8%, and 18.6%, respectively for the corresponding nondiabetics, prediabetics and various DM subgroups. Conclusion: Significant prevalence of CKD were found in prediabetics of NYC Chinese and general populations. There is a high prevalence of CKD associated with diabetes mellitus in both populations. Prevalence of CKD in NYC Chinese is higher than the general population, particularly in the ≥65 years group and those having severer DM with A1C >8.0. Disclosure T. Chang: None. G. Liu: None. J.D. George: None. J.W. Sharp: None. A. Hu: None.