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Your search keyword '"Turnbull, Douglass M."' showing total 9 results
Start Over Author "Turnbull, Douglass M." Journal diabetes
9 results on '"Turnbull, Douglass M."'

4. Decreased Insulin Responsiveness of Glucose Uptake in Cultured Human Skeletal Muscle Cells From Insulin-Resistant Nondiabetic Relatives of 2 Diabetic Families

Author

Jackson, Sandra, Bagstaff, Stephanie M., Lynn, Stephen, Yeaman, Stephen J., Turnbull, Douglass M., and Walker, Mark

Subjects
Familial diseases -- Research -- Development and progression -- Genetic aspects, Insulin resistance -- Genetic aspects -- Development and progression -- Research, Type 2 diabetes -- Development and progression -- Research -- Genetic aspects, Health, Development and progression, Research, Genetic aspects
Abstract

To investigate the contribution of inherited biochemical defects to the peripheral insulin resistance of type 2 diabetes, we studied cultured skeletal muscle from 10 insulin-resistant nondiabetic first-degree relatives of type [...]

Published
2000

5. The Mitochondrial DNA A3243G Mutation in Single Pancreatic Cells: Increased Sensitivity to Pathogenic Point Mutations?

Author

LYNN, STEPHEN, JOHNSON, MARGARET A., TURNBULL, DOUGLASS M., and WALKER, MARK

Subjects
Diabetes -- Research, Disease susceptibility -- Research, Pancreas -- Secretions, Insulin -- Physiological aspects, Health
Abstract

Many mitochondrial DNA (mtDNA) mutations have been associated with diabetes mellitus (DM), in which impaired insulin secretion is a key feature. Therefore, the pancreatic [Beta]-cell is a likely target for [...]

Published
2000

6. Variation in the Calpain 10 Gene Is Associated with Glucose Tolerance in Non-Diabetic European Caucasians

Author

WALKER, MARK, LYNN, STEPHEN, WHITE, CHRISTOPHER B., EVANS, JULIE C., and TURNBULL, DOUGLASS M.

Subjects
Glucose metabolism -- Genetic aspects, Type 2 diabetes -- Genetic aspects, Mexican Americans -- Health aspects, Health
Abstract

Recent studies suggest that genetic variation in the calpain 10 gene is associated with type 2 diabetes mellitus in Mexican American and other populations. We investigated whether G/A (UCSNP-43) and [...]

Published
2000

9. Mitochondrial Diabetes.

Author

Lynn, Stephen, Wardell, Theresa, Johnson, Margaret A., Chinnery, Patrick F., Daly, Mark E., Walker, Mark, and Turnbull, Douglass M.

Subjects
GENETICS of diabetes, MITOCHONDRIAL DNA
Abstract

Examines the genetic defects in mitochondrial diabetes. Structure of mitochondrial genome; Identification of mitochondrial DNA point mutations and rearrangements in families with diabetes; Major factor limiting the identification of the DNA defects in diabetes.

Published
1998

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