Search

Background: Short-term continuous subcutaneous insulin infusion treatment (CSII) in patients with newly diagnosed type 2 diabetes (T2DM) can improve β-cell function and insulin sensitivity, which results in long-term remission. However, the effect of CSII on peripheral neuropathy is rarely studied. Methods: 63 T2DM patients (HbA1c>9%) were hospitalized and treated with CSII for 2 weeks. Peripheral autonomic neuropathy was measured by SUDOSCAN, which provides an age adjusted electrochemical skin conductance (ESC) composite score incorporating hands/feet ESC measurements, with a score ≤60 indicating sudomotor dysfunction. Blood glucose, HbA1c, C-peptide and SUDOSCAN were measured before and after CSII. HOMA-B was used for assessment of β-cell function. Results: The average HbA1c of included patients was 10.5% with median duration of T2DM was 3.5 years. There were 27 (42.9%) patients who had sudomotor dysfunction at baseline. After 2 weeks of CSII, the proportion of sudomotor dysfunction (42.9% vs. 31.7%, P=0.020) was significantly deceased along with significantly improved HbA1c (10.0±1.9 vs. 8.1±1.0, P Conclusion: Peripheral autonomic neuropathy could be improved by CSII in T2DM. The improvement of β-cell function could be responsible for the amelioration of peripheral nerve function. Keywords: Short-term continuous subcutaneous insulin infusion treatment; peripheral autonomic neuropathy; type 2 diabetes; β-cell function Disclosure J.Jin:None. Funding National Key R&D Program of China (2018YFC1314100) ; the Key-Area Research and Development Program ofGuangdong Province (2019B020230001) ; the China Postdoctoral ScienceFoundation (2018M640871)

Background: Diabetes mellitus is a risk factor for perioperative major adverse events. This study aims to evaluate the association between prior bariatric surgery (prior-BS) and perioperative cardiovascular outcomes following noncardiac surgery in patients with type 2 diabetes mellitus (T2DM). Methods: We used the National Inpatient Database to identify major noncardiac surgery in T2DM patients from 2006 to 2014. The primary outcome is major perioperative adverse cardiovascular and cerebrovascular events (MACCE), which included death, acute myocardial infarction and acute ischemic stroke. In-hospital outcomes between patients with prior-BS and morbid obesity were compared using unadjusted logistic, multivariable logistic and propensity score matching analyses. Results: A weighted of 152,6820 patients diagnosed with T2DM who underwent noncardiac surgery were included. Both rates of prior-BS and morbid obesity significantly increased during the study period (P Conclusions: Prior bariatric surgery in diabetes mellitus patients who underwent noncardiac surgery is associated with lower risk of MACCE. Prospective studies are need to verify the benefits of bariatric surgery in noncardiac surgery. Disclosure J. Jin: None. H. Li: None. P. Zhang: None. Y. Li: None. Funding China Postdoctoral Science Foundation (2018M640871)