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5 results on '"Glucose metabolism -- Models"'

1. Portal Glucose Infusion in the Mouse Induces Hypoglycemia

Author

Burcelin, Remy, Dolci, Wanda, and Thorens, Bernard

Subjects
Glucose metabolism -- Models, Hypoglycemia -- Models, Health, Models
Abstract

Evidence That the Hepatoportal Glucose Sensor Stimulates Glucose Utilization To analyze the role of the murine hepatoportal glucose sensor in the control of whole-body glucose metabolism, we infused glucose at [...]

Published
2000

2. Role of Insulin Receptor Substrate-1 in Islet Function

Author

SATOH, SHINOBU, UDAKA, NAOKO, ITO, TAKAAKI, EGAWA, MASATO, ETO, KAZUHIRO, KADOWAKI, TAKASHI, and SEKIHARA, HISAHIKO

Subjects
Insulin -- Receptors, Pancreatic beta cells -- Physiological aspects, Glucose metabolism -- Models, Health
Abstract

To investigate the role of IRS-1 in endocrine pancreatic function, we have performed in vivo experiments of islet function in mice with knockout mutations in Insulin Receptor Substrate (IRS)-1 (IRS-1-/-), [...]

Published
2000

3. Activation of p38 Mitogen-Activated Protein Kinase Alpha and Beta Isoforms by Insulin in Rat Skeletal Muscle: Participation in the Stimulation of Glucose Transport

Author

SOMWAR, ROMEL, PERREAULT, MYLENE, KAPUR, SONIA, TAHA, CELIA, KIM, DAVID Y., SWEENEY, GARY, RAMLAL, TOOLSIE, COTE, CLAUDE H., KLIP, AMIRA, and MARETTE, ANDRE

Subjects
Protein kinases -- Physiological aspects, Glucose metabolism -- Models, Health
Abstract

We have previously shown that SB203580, an inhibitor of p38 mitogen-activated protein kinase (p38MAPK), attenuated insulin-stimulated glucose uptake in L6 skeletal muscle cells and 3T3-L1 adipocytes. Here we further explore [...]

Published
2000

4. Insulinotropic Glucagon-Like Peptide 1 Agonists Stimulate Expression of Homeodomain Protein IDX-1 and Increase Islet Size in Mouse Pancreas

Author

Stoffers, Doris A., Kieffer, Timothy J., Hussain, Mehboob A., Drucker, Daniel J., Bonner-Weir, Susan, Habener, Joel F., and Egan, Josephine M.

Subjects
Pancreatic beta cells -- Physiological aspects, Glucose metabolism -- Models, Health
Abstract

Diabetes is caused by a failure of the pancreas to produce insulin in amounts sufficient to meet the body's needs. A hallmark of diabetes is an absolute (type 1) or [...]

Published
2000

5. Effects of Thiazolidinediones on CETP/ApoB-100 Double Transgenic Mice Made Obese and Insulin Resistant by High Fat/High Carbohydrate Feeding

Author

CAMEJO, GERMAN, WALLIN, BOEL, AMROT-FORS, LENA, KJELLSTEDT, ANN, SVENSSON, LENNART, and LJUNG, BENGT

Subjects
Insulin resistance -- Physiological aspects, Thiazolidinediones -- Health aspects, Glucose metabolism -- Models, Diabetes -- Research, Health
Abstract

Obese rodents with single gene defects, like the Zucker rat and the ob/ob mouse, may not be optimal models of the multifactorial obesity associated with human insulin resistance. Mice strains [...]

Published
1999

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