1. Managing coeliac disease in patients with diabetes
- Author
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Alessio Fasano, Maureen M. Leonard, and Pamela Cureton
- Subjects
medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Autoimmunity ,medicine.disease_cause ,Gastroenterology ,Severity of Illness Index ,Coeliac disease ,Pathogenesis ,Diabetes Complications ,Diet, Gluten-Free ,Endocrinology ,Diabetes mellitus ,Internal medicine ,Diet, Diabetic ,Internal Medicine ,Genetic predisposition ,Medicine ,Animals ,Humans ,Intensive care medicine ,chemistry.chemical_classification ,Type 1 diabetes ,Evidence-Based Medicine ,business.industry ,nutritional and metabolic diseases ,medicine.disease ,Gluten ,digestive system diseases ,Celiac Disease ,Diabetes Mellitus, Type 1 ,chemistry ,Patient Compliance ,Gluten free ,business - Abstract
The association between coeliac disease and type 1 diabetes has long been established. The combination of genetic susceptibility along with a potential role for gluten in the pathogenesis of autoimmunity makes defining gluten's role in type 1 diabetes extremely important. Evidence supporting the role of a gluten-free diet to improve complications associated with type 1 diabetes is not robust. However there is evidence to support improved growth, bone density and potentially the prevention of additional autoimmune diseases in patients with coeliac disease and type 1 diabetes. The gluten free diet is expensive and challenging to adhere to in people already on a modified diet. Early identification of those who have coeliac disease and would benefit from a gluten-free diet is of utmost importance to prevent complications associated with type 1 diabetes and coeliac disease.
- Published
- 2014