1. Motor function domains in alternating hemiplegia of childhood
- Author
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Jeffrey Wuchich, Amanda Hall, Lyndsey Prange, Mohamad A. Mikati, Kelly J. Gordon, Melissa McLean, Kara L. Lardinois, Joan Jasien, Julie Uchitel, and Melanie Masoud
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Gross motor skill ,Population ,Hemiplegia ,Audiology ,Severity of Illness Index ,Speech Disorders ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Developmental Neuroscience ,030225 pediatrics ,Motor speech ,Severity of illness ,medicine ,Humans ,education ,Child ,education.field_of_study ,Movement Disorders ,Alternating hemiplegia of childhood ,Motor control ,Infant ,Gross Motor Function Classification System ,medicine.disease ,Dysphagia ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Physical therapy ,Female ,Neurology (clinical) ,medicine.symptom ,Psychology ,Deglutition Disorders ,030217 neurology & neurosurgery - Abstract
Aim To characterize motor function profiles in alternating hemiplegia of childhood, and to investigate interrelationships between these domains and with age. Method We studied a cohort of 23 patients (9 males, 14 females; mean age 9y 4mo, range 4mo–43y) who underwent standardized tests to assess gross motor, upper extremity motor control, motor speech, and dysphagia functions. Results Gross Motor Function Classification System (GMFCS), Gross Motor Function Measure-88 (GMFM-88), Manual Ability Classification System (MACS), and Revised Melbourne Assessment (MA2) scales manifested predominantly mild impairments; motor speech, moderate to severe; Modified Dysphagia Outcome and Severity Scale (M-DOSS), mild-to moderate deficits. GMFCS correlated with GMFM-88 scores (Pearson's correlation, p=0.002), MACS (p=0.038), and MA2 fluency (p=0.005) and accuracy (p=0.038) scores. GMFCS did not correlate with motor speech (p=0.399), MA2 dexterity (p=0.247), range of motion (p=0.063), or M-DOSS (p=0.856). Motor speech was more severely impaired than the GMFCS (p
- Published
- 2017