151. Neurocognitive outcome in young adults born late-preterm.
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Heinonen, Kati, Lahti, Jari, Sammallahti, Sara, Wolke, Dieter, Lano, Aulikki, Andersson, Sture, Pesonen, Anu‐Katriina, Eriksson, Johan G., Kajantie, Eero, Raikkonen, Katri, and Pesonen, Anu-Katriina
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COGNITION disorders , *PREMATURE labor , *GESTATIONAL age , *EXECUTIVE function , *MEMORY testing , *TESTING , *COGNITION disorders diagnosis , *BIRTH size , *COMPARATIVE studies , *PREMATURE infants , *INTELLECT , *INTELLIGENCE tests , *LONGITUDINAL method , *NEUROPSYCHOLOGICAL tests , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *EVALUATION research - Abstract
Aim: This study examined whether late-preterm birth (34+0 to 36+6wks+d gestational age) was associated with neurocognitive deficit in young adulthood, and whether small for gestational age (SGA) birth amplified any adversity.Method: Participants derived from the prospective regional cohort study, the Arvo Ylppö Longitudinal Study (n=786; 398 females, 388 males) (mean age 25y 4mo, SD 8mo), born 1985 to 1986 late-preterm (n=119; 21 SGA, <-2 SD) and at term (37+0 to 41+6wks+d; n=667; 28 SGA) underwent tests of intelligence, executive functioning, attention, and memory, and reported their education.Results: Those born late-preterm scored -3.71 (95% confidence interval [CI] -6.71 to -0.72) and -3.11 (95% CI -6.01 to -0.22) points lower on Full-scale and Verbal IQ than peers born at term. Compared with those born at term and appropriate for gestational age (≥-2 to <2 SD) Full-scale, Verbal, and Performance IQ scores of those born late-preterm and SGA were -9.45 to -11.84 points lower. After adjustments, differences were rendered non-significant, except that scores in Full-scale and Performance IQ remained lower among those born late-preterm and SGA.Interpretation: Late-preterm birth, per se, may not increase the risk of poorer neurocognitive functioning in adulthood. But the double burden of being born late-preterm and SGA seems to increase this risk.What This Paper Adds: Late-preterm birth did not increase the risk of poorer neurocognitive functioning in adulthood. But the double burden of being born late-preterm and being small for gestational age did increase this risk. [ABSTRACT FROM AUTHOR]- Published
- 2018
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