1. Identification of embryonic pancreatic genes usingXenopusDNA microarrays
- Author
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Tadayoshi Hayata, Ira L. Blitz, Ken W.Y. Cho, and Nahoko Iwata
- Subjects
medicine.medical_specialty ,Molecular Sequence Data ,Xenopus ,Organogenesis ,Xenopus Proteins ,Article ,Receptors, G-Protein-Coupled ,Xenopus laevis ,Molecular genetics ,Diabetes Mellitus ,medicine ,Animals ,Cluster Analysis ,Humans ,Glucose homeostasis ,Hedgehog Proteins ,Pancreas ,In Situ Hybridization ,Oligonucleotide Array Sequence Analysis ,biology ,Microarray analysis techniques ,Embryogenesis ,Gene Expression Regulation, Developmental ,Foregut ,biology.organism_classification ,Molecular biology ,Frizzled Receptors ,Fibroblast Growth Factors ,Wnt Proteins ,medicine.anatomical_structure ,Immunoglobulin J Recombination Signal Sequence-Binding Protein ,Biomarkers ,Signal Transduction ,Developmental Biology - Abstract
The pancreas is both an exocrine and endocrine endodermal organ involved in digestion and glucose homeostasis. During embryogenesis, the anlagen of the pancreas arise from dorsal and ventral evaginations of the foregut that later fuse to form a single organ. To better understand the molecular genetics of early pancreas development, we sought to isolate markers that are uniquely expressed in this tissue. Microarray analysis was performed comparing dissected pancreatic buds, liver buds, and the stomach region of tadpole stage Xenopus embryos. A total of 912 genes were found to be differentially expressed between these organs during early stages of organogenesis. K-means clustering analysis predicted 120 of these genes to be specifically enriched in the pancreas. Of these, we report on the novel expression patterns of 24 genes. Our analyses implicate the involvement of previously unsuspected signaling pathways during early pancreas development. Developmental Dynamics 238:1455-1466, 2009. (c) 2009 Wiley-Liss, Inc.
- Published
- 2009