1. Regenerative Neurogenesis from Neural Progenitor Cells Requires Injury-Induced Expression of Gata3
- Author
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Dorian Freudenreich, Nikos Kyritsis, Caghan Kizil, Jan Kaslin, Volker Kroehne, Michael Brand, and Stefanie Dudczig
- Subjects
Telencephalon ,Neurogenesis ,GATA3 Transcription Factor ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Animals, Genetically Modified ,Neural Stem Cells ,Cell Movement ,Animals ,Molecular Biology ,Zebrafish ,Transcription factor ,Cell Proliferation ,Inflammation ,Neurons ,Wound Healing ,GATA3 ,Brain ,Cell Biology ,Zebrafish Proteins ,biology.organism_classification ,Neural stem cell ,Nerve Regeneration ,Cell biology ,Fibroblast Growth Factors ,Brain Injuries ,Immunology ,Stem cell ,Signal transduction ,Wound healing ,Neuroglia ,Signal Transduction ,Developmental Biology - Abstract
SummaryThe adult zebrafish brain, unlike mammalian counterparts, can regenerate after injury owing to the neurogenic capacity of stem cells with radial glial character. We hypothesized that injury-induced regenerative programs might be turned on after injury in zebrafish brain and enable regenerative neurogenesis. Here we identify one such gene—the transcription factor gata3—which is expressed only after injury in different zebrafish organs. Gata3 is required for reactive proliferation of radial glia cells, subsequent regenerative neurogenesis, and migration of the newborn neurons. We found that these regeneration-specific roles of Gata3 are dependent on the injury because Gata3 overexpression in the unlesioned adult zebrafish brain is not sufficient to induce neurogenesis. Thus, gata3 acts as a specific injury-induced proregenerative factor that is essential for the regenerative capacity in vertebrates.
- Published
- 2012
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