1. A switch in pdgfrb
- Author
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Vasiliki, Tsata, Stephanie, Möllmert, Christine, Schweitzer, Julia, Kolb, Conrad, Möckel, Benjamin, Böhm, Gonzalo, Rosso, Christian, Lange, Mathias, Lesche, Juliane, Hammer, Gokul, Kesavan, Dimitris, Beis, Jochen, Guck, Michael, Brand, and Daniel, Wehner
- Subjects
Receptor, Platelet-Derived Growth Factor beta ,Cicatrix ,Spinal Cord ,Animals ,Recovery of Function ,Zebrafish Proteins ,Models, Biological ,Axons ,Spinal Cord Injuries ,Zebrafish ,Extracellular Matrix ,Nerve Regeneration ,Signal Transduction - Abstract
In mammals, perivascular cell-derived scarring after spinal cord injury impedes axonal regrowth. In contrast, the extracellular matrix (ECM) in the spinal lesion site of zebrafish is permissive and required for axon regeneration. However, the cellular mechanisms underlying this interspecies difference have not been investigated. Here, we show that an injury to the zebrafish spinal cord triggers recruitment of pdgfrb
- Published
- 2020