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Early neocortical injury has been associated with rate-specific auditory processing deficits using rodent models. In the few cases where females were studied, they appeared less vulnerable than males to the behavioral consequences of early neocortical injury. In the current study, male rats with neocortical microgyria were found to exhibit significant impairments in detecting tone sequences at short but not long inter-stimulus intervals (ISI) as compared to sham-operated male littermates. Microgyric females, however, performed similarly to sham-operated female littermates on this task at all durations. Current findings support an association between focal cortical malformations and impaired rapid auditory processing in males, and less vulnerability in females to the behavioral consequences of these malformations on a task eliminating confounds of motivation, experience, and estrus. [Copyright &y& Elsevier]

Adult male rats with induced microgyric lesions exhibit significant deficits in rapid auditory processing, as well as morphological alterations in the medial geniculate nucleus (MGN) of the thalamus. These findings are considered striking in light of similar anatomical and auditory processing anomalies in language disabled humans. Given evidence from clinical and animal studies that acoustic experience may alter sensory processing at behavioral and neurophysiological levels, the current study examined effects of developmental exposure to auditory stimulation on behavioral and anatomical indices in microgyric and sham rats. Stimulation (E7–P70) included: (1) chronic white noise (80 dB) with standard housing; (2) 3 h/day of 78 dB filtered light classical music with social housing; or (3) standard acoustic environment (control) with standard housing. Microgyric effects on auditory processing and thalamic morphology were evident regardless of environmental condition. In sum, the effects of microgyria on brain and behavior appear to be robust, and largely orthogonal to any main effect of acoustic stimulation on auditory processing. These findings suggest that a more active form of acoustic stimulation (e.g., training) may be required to ameliorate the deleterious behavioral and anatomical consequences of focal microgyric lesions. [Copyright &y& Elsevier]

Previous research with adult animal models links the presence of cortical neuromigrational anomalies (i.e., microgyria similar to that found in brains of dyslexics) with rapid auditory processing (RAP) impairments. RAP impairments are in turn found in children with specific language impairment (SLI) and also in individuals with dyslexia. Gap detection, a simple measure of auditory temporal acuity, appears to be impaired in children with SLI but not in dyslexic adults, even though both groups exhibit impaired processing on more complex, rapid auditory tasks. In the current study, juvenile rats with bilateral microgyria, but not their adult counterparts, exhibited impaired detection of short duration silent gaps in white noise when compared to age-matched sham littermates. Results lend further support to: (1) an association between neuromigrational anomalies and RAP impairments; and (2) the validity of an animal model of RAP impairments associated with language disturbances in humans. Current results also support the view that auditory processing disturbances associated with cortical malformations may be evident early in development at a relatively “low” level (e.g., simple gap detection), but may require “higher-order” auditory discrimination tasks (e.g., tone sequences, phonemic discriminations) to be elicited later in life. [Copyright &y& Elsevier]