1. Ftm is a novel basal body protein of cilia involved in Shh signalling.
- Author
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Vierkotten J, Dildrop R, Peters T, Wang B, and Rüther U
- Subjects
- Adaptor Proteins, Signal Transducing chemistry, Animals, Cells, Cultured, Embryo, Mammalian metabolism, Extremities embryology, Extremities growth & development, Kruppel-Like Transcription Factors metabolism, Mice, Mice, Knockout, Mutation, Nerve Tissue Proteins metabolism, Neural Tube Defects genetics, Neural Tube Defects metabolism, Phenotype, Polydactyly genetics, Polydactyly metabolism, Zinc Finger Protein Gli3, Adaptor Proteins, Signal Transducing physiology, Body Patterning physiology, Cilia metabolism, Hedgehog Proteins metabolism, Signal Transduction
- Abstract
In this study we show in mice that Ftm (Rpgrip1l) is located at the ciliary basal body. Our data reveal that Ftm is necessary for developmental processes such as the establishment of left-right asymmetry and patterning of the neural tube and the limbs. The loss of Ftm affects the ratio of Gli3 activator to Gli3 repressor, suggesting an involvement of Ftm in Shh signalling. As Ftm is not essential for cilia assembly but for full Shh response, Ftm can be considered as a novel component for cilium-related Hh signalling. Furthermore, the absence of Ftm in arthropods underlines the divergence between vertebrate and Drosophila Hh pathways.
- Published
- 2007
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