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2. Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth

Author

Colombo, Alicia, primary, Palma, Karina, additional, Armijo, Lorena, additional, Mione, Marina, additional, Signore, Iskra A., additional, Morales, Camila, additional, Guerrero, Néstor, additional, Meynard, Margarita M., additional, Pérez, Ramón, additional, Suazo, José, additional, Marcelain, Katherine, additional, Briones, Luis, additional, Härtel, Steffen, additional, Wilson, Stephen W., additional, and Concha, Miguel L., additional

Published
2013
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3. Planar cell polarity signalling regulates cell adhesion properties in progenitors of the zebrafish laterality organ

Author

Oteiza, Pablo, primary, Köppen, Mathias, additional, Krieg, Michael, additional, Pulgar, Eduardo, additional, Farias, Cecilia, additional, Melo, Cristina, additional, Preibisch, Stephan, additional, Müller, Daniel, additional, Tada, Masazumi, additional, Hartel, Steffen, additional, Heisenberg, Carl-Philipp, additional, and Concha, Miguel L., additional

Published
2010
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4. Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer

Author

Castillo, Hozana A., primary, Cravo, Roberta M., additional, Azambuja, Ana P., additional, Simões-Costa, Marcos S., additional, Sura-Trueba, Sylvia, additional, Gonzalez, Jose, additional, Slonimsky, Esfir, additional, Almeida, Karla, additional, Abreu, José G., additional, de Almeida, Marcio A. Afonso, additional, Sobreira, Tiago P., additional, de Oliveira, Saulo H. Pires, additional, de Oliveira, Paulo S. Lopes, additional, Signore, Iskra A., additional, Colombo, Alicia, additional, Concha, Miguel L., additional, Spengler, Tatjana S., additional, Bronner-Fraser, Marianne, additional, Nobrega, Marcelo, additional, Rosenthal, Nadia, additional, and Xavier-Neto, José, additional

Published
2010
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11. parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube

Author

Lele, Zsolt, Folchert, Anja, Concha, Miguel, Rauch, Gerd-Jörg, Geisler, Robert, Rosa, Frédéric, Wilson, Steve W., Hammerschmidt, Matthias, and Bally-Cuif, Laure

Abstract

N-cadherin (Ncad) is a classical cadherin that is implicated in several aspects of vertebrate embryonic development, including somitogenesis, heart morphogenesis, neural tube formation and establishment of left-right asymmetry. However, genetic in vivo analyses of its role during neural development have been rather limited. We report the isolation and characterization of the zebrafish parachute (pac) mutations. By mapping and candidate gene analysis, we demonstrate that pac corresponds to a zebrafish n-cadherin (ncad) homolog. Three mutant alleles were sequenced and each is likely to encode a non-functional Ncad protein. All result in a similar neural tube phenotype that is most prominent in the midbrain, hindbrain and the posterior spinal cord. Neuroectodermal cell adhesion is altered, and convergent cell movements during neurulation are severely compromised. In addition, many neurons become progressively displaced along the dorsoventral and the anteroposterior axes. At the cellular level, loss of Ncad affects β-catenin stabilization/localization and causes mispositioned and increased mitoses in the dorsal midbrain and hindbrain, a phenotype later correlated with enhanced apoptosis and the appearance of ectopic neurons in these areas. Our results thus highlight novel and crucial in vivo roles for Ncad in the control of cell convergence, maintenance of neuronal positioning and dorsal cell proliferation during vertebrate neural tube development.

Published
2002
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