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Start Over Author "M.T. Fernández Figueras" Journal dermatology
2 results on '"M.T. Fernández Figueras"'

1. Newsletter No. 17

Author

Sami Abdennader, T. Schneiter, Jie Zheng, H. Coignard, Martin Leverkus, Marie-Dominique Vignon-Pennamen, Werner Kempf, B. Cribier, Pascal Reygagne, Bungo Ohyama, Ying-Wei Chen, Druck Reinhardt Druck Basel, K.D. Mertz, Georg Stingl, Christine Bangert, Brigitte Peters, Hirohiko Sueki, K. Kerl, A. Fourtanier, Thomas Bieber, Olivier Join-Lambert, Peter Itin, Hayriye Sarıcaoğlu, Daniele Castiglia, C. Mainetti, A.C. Green, P. Giovanoli, Achim Guettner, P. McBride, Yoko Nagashima, G. Palmedo, I. Kolm, Erwin Kump, Han Tian, W. Kempf, Sara Pruneddu, Stephen K. Tyring, Anne-Sophie Le Guern, M. Schmid, Alexander Rufle, Hélène Guet-Revillet, Masumi Akita, Xavier Nassif, Alessandro Giunta, P. Itin, T. Hunziker, Anne Leflèche, Adam Ferguson, Hakan Turan, Wie Huang, Jean-Paul Ortonne, Sylvain Poirée, Sergio Chimenti, Tetsuya Tsuchida, Michael J. Cork, Florence Ribadeau-Dumas, M. Pfaltz, Sylvie Behillil, M. Pithon, Jens Ulrich, Sophia Weise-Riccardi, R.P. Braun, Zhen-Min Niu, L. Schärer, Francesca Cottoni, Peter Häusermann, Andreas W. Arnold, Harald Gollnick, Anna Pokrywka, M.T. Fernández Figueras, Paul Henri Consigny, Jean-Philippe Jais, J. Kamarashev, Daniela Göppner, Jing Zhang, Tamara Kopp, Patrick Berche, Alessandro Di Stefani, Sylvie Fraitag, Koji Iida, B. Burger, Wen-Tao Yuan, Jacques Thèze, Vincent Jullien, Jean Hatchuel, Thomas A. Luger, Giovanna Floriddia, A. Andrade, Rupert C. Ecker, Giovanna Zambruno, Xiao-Ying Chen, Bettina Burger, M.C.B. Hughes, Bruce Strober, Li-Wei Jin, Arife Oz, Olivier Lortholary, Aude Nassif, Takashi Hashimoto, Satz Mengensatzproduktion, L.E. French, Norito Ishii, and H. Kutzner

Subjects
medicine.medical_specialty, business.industry, Medicine, Library science, Dermatology, business
Published
2011

2. Detection of Merkel Cell Polyomavirus in Epidermodysplasia-Verruciformis-Associated Skin Neoplasms

Author

Peter Itin, Gabriele Palmedo, Kirsten D. Mertz, Bettina Burger, Werner Kempf, Michael Schmid, M.T. Fernández Figueras, Heinz Kutzner, Bernard Cribier, Madeleine Pfaltz, L. Schärer, University of Zurich, and Kempf, W

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Skin Neoplasms, Cell, MCPyV Infection, Merkel cell polyomavirus, 610 Medicine & health, Dermatology, 2708 Dermatology, Immunocompromised Host, Genotype, medicine, Betapapillomavirus, Humans, Genetic Predisposition to Disease, Common warts, Aged, Aged, 80 and over, Polyomavirus Infections, biology, Genodermatosis, 10177 Dermatology Clinic, virus diseases, Epidermodysplasia verruciformis, Middle Aged, biology.organism_classification, medicine.disease, Carcinoma, Merkel Cell, Tumor Virus Infections, medicine.anatomical_structure, Epidermodysplasia Verruciformis, Female, Polyomavirus, Normal skin
Abstract

Background: Epidermodysplasia verruciformis (EV) is a rare genodermatosis that is characterized by susceptibility to infection with specific human papillomavirus (HPV) genotypes. Among polyomaviruses, the novel Merkel cell polyomavirus (MCPyV) has been found in different epithelial skin neoplasias. Objective: To examine whether EV is associated with cutaneous MCPyV infection. Methods: We used MCPyV-specific PCR to study skin neoplasms of 6 congenital EV patients and of 1 patient with acquired EV. Results: In all congenital EV patients, MCPyV DNA was found in carcinomas in situ, in invasive squamous cell carcinomas and in common warts. In 4 of these patients, the MCPyV-positive skin lesions were from different anatomic locations. In addition, 1 immunosuppressed patient suffering from acquired EV harbored MCPyV DNA in 2 common warts. In contrast, 7 normal skin samples tested negative for MCPyV DNA. Only 2 out of 24 carcinomas in situ (8.3%) and 2 out of 30 common warts (6.7%) from immunocompetent individuals were positive for MCPyV DNA. Conclusions: The strong association of EV-associated skin neoplasms with MCPyV suggests a unique susceptibility of EV patients to infections with MCPyV. Both MCPyV and EV-HPV may act as synergistic oncogenic cofactors in the development of EV-associated skin neoplasms.

Published
2010

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