1. Prevalence of Merkel Cell Polyomavirus among Swiss Merkel Cell Carcinoma Patients
- Author
-
Katrin Kerl, Reinhard Dummer, Antonio Cozzio, Piotr Dziunycz, Joanna Mangana, University of Zurich, and Cozzio, A
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Skin Neoplasms ,Merkel cell polyomavirus ,610 Medicine & health ,Dermatology ,Biology ,Merkel Cells ,2708 Dermatology ,Prevalence ,Carcinoma ,medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,Polyomavirus Infections ,Merkel cell carcinoma ,Incidence ,10177 Dermatology Clinic ,food and beverages ,Cancer ,medicine.disease ,biology.organism_classification ,Carcinoma, Merkel Cell ,medicine.anatomical_structure ,Female ,Viral disease ,Skin cancer ,Polyomavirus ,Merkel cell ,Switzerland ,Oncovirus - Abstract
Background: Merkel cell carcinoma (MCC) is a malignant neuroendocrine neoplasm which shares structural and immunohistochemical features with neuroectodermally derived cells. One hypothesis claims that it arises from Merkel cells, highly innervated neuroendocrine cells involved in mechanoreception in the skin. The incidence rate of this cancer increases with age and sun exposure as well as after immunosuppression. Recently, the clonal integration of a newly identified polyomavirus called Merkel cell polyomavirus (MCPyV) was reported in up to 80% of MCC tissue. Here we report the incidence rate of MCPyV in MCC patients in Switzerland. Methods: We performed polymerase chain reaction in a collection of 32 samples obtained from pathology institutes around Switzerland. We used three different published primer sets. As control groups we used 7 squamous cell carcinoma samples and 11 normal skin samples. Conclusions: We detected viral DNA in 20 out of 30 cases of MCC and in 0 out of 19 control samples. The presence of viral DNA in 66.6% of our MCC tissue specimens confirms the high prevalence of MCPyV in MCC patients described in American, German, French and Hungarian patient collections.
- Published
- 2010