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A case report of febrile neutrophilic dermatosis as previously described by Sweet. The acute febrile illness is accompanied by plaque eruption and a positive toxoplasma indirect fluorescent antibody (IFA) test. Moreover, clinical and histopathological manifestations were compatible with the cutaneous reactive manifestation of toxoplasmosis and disappeared only after specific therapy.

Two sibs with palmo-plantar keratosis and dendritic corneal opacities, previously described as suffering from Richner-Hanhart syndrome by other authors, about 25 years ago, showed increased plasma and urine tyrosine levels. Their neurological and mental features were within normal limits. A comprehensive review of the literature showed a total of 47 cases of fully documented tyrosinemia type II; 8 more patients also had the clinical features of the disease, but aminoacidemia had never been observed. The importance of early diagnosis is stressed, since a low tyrosine-phenylalanine diet dramatically improves the symptoms and may prevent mental retardation.

A case of lipoatrophia semicircularis is described in a 5-year-old child. Histological examination revealed the complete loss of adipose tissue. No associated abnormalities were found.