1. Do acne treatments affect insulin-like growth factor-1 serum levels? A clinical and laboratory study on patients with acne vulgaris.
- Author
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Rodighiero E, Bertolani M, Saleri R, Pedrazzi G, Lotti T, Feliciani C, and Satolli F
- Subjects
- Adolescent, Adult, Humans, Isotretinoin, Laboratories, Young Adult, Acne Vulgaris diagnosis, Acne Vulgaris drug therapy, Insulin-Like Growth Factor I
- Abstract
Acne is a chronic inflammatory disease affecting sebaceous gland follicles. Lately, acne has considered an insulin-like growth factor-1 (IGF-1) mediated disease. Recent research demonstrated that IGF-1 levels decrease after 3 months of isotretinoin. The purpose of our study is evaluating the influence of acne treatments on IGF-1 serum levels. Forty-six subjects with acne vulgaris aged 14 to 30 years were subdivided into three groups according to their severity of acne and treated following the European Dermatology Forum guidelines. IGF-1 was measured in patients before and after the treatment and then compared to the IGF-1 of a healthy population of the same age. IGF-1 resulted higher in patients than in controls but there was not a statistically significant variation after treatment. To the best of our knowledge, this is the first study evaluating the influence of topical and systemic acne treatment on IGF-1 serum levels. In contrast with the literature, our results suggest that common therapies for acne are not able to significantly modify IGF-1 serum levels., (© 2020 Wiley Periodicals LLC.)
- Published
- 2020
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