1. Fractal dimension evaluation of cone beam computed tomography in patients with bisphosphonate-associated osteonecrosis
- Author
-
Lars Hollender, P. P. Lee, Sandra Torres, C. S K Chen, Brian G. Leroux, and Mark M. Schubert
- Subjects
Adult ,Male ,Cone beam computed tomography ,Short Communication ,Mandibular canal ,Dentistry ,Pilot Projects ,Mental foramen ,stomatognathic system ,Region of interest ,mental disorders ,medicine ,Humans ,Mandibular Diseases ,Single-Blind Method ,Radiology, Nuclear Medicine and imaging ,General Dentistry ,Generalized estimating equation ,Aged ,Retrospective Studies ,Aged, 80 and over ,Bone Density Conservation Agents ,Diphosphonates ,business.industry ,Osteonecrosis ,Mandible ,Mandibular foramen ,General Medicine ,Cone-Beam Computed Tomography ,Middle Aged ,nervous system diseases ,Fractals ,Logistic Models ,medicine.anatomical_structure ,nervous system ,Otorhinolaryngology ,Case-Control Studies ,Regression Analysis ,Female ,Nuclear medicine ,business ,psychological phenomena and processes - Abstract
The aim of this study was to (1) evaluate the fractal dimension (FD) in regions of the mandible on cone beam CT (CBCT) images of patients with bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ) and (2) to select the most suitable region of interest (ROI) for further study on detection of bone alterations associated with bisphosphonates.CBCT images of patients with BP-ONJ were included with matched controls. Values of FD were compared between groups. Selected ROIs were: ROI-1 - below the mandibular foramen; ROI-2 - above the mandibular foramen; ROI-3 - anterior to the mental foramen; ROI-4 - above the mandibular canal. The area of bone exposure was included as ROI-5. The results were analysed using generalized estimating equations and conditional logistic regression.There were 36 patients (67% female) with a mean age of 60.7 years. The mean FDs were: ROI-1 - 1.678 for controls and 1.673 for patients (P = 0.81); ROI-2 - 1.657 for controls and 1.653 for patients (P = 0.78); ROI-3 - 1.661 for controls and 1.684 for patients (P = 0.17); and ROI-4 - 1.670 for controls and 1.698 for patients (P = 0.03). The value of the FD in the area of exposed bone was the highest (1.729). The odds of being a BP-ONJ patient vs being a control was six times as high for individuals with a higher FD score at ROI-4, although the confidence interval was quite wide owing to the small sample size.In this preliminary study, BP-ONJ patients had higher FD values than controls at regions close to the alveolar process. The results suggest that FD is a promising tool for detection of bone alterations associated with BP-ONJ.
- Published
- 2011