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Start Over Author "Peter, Passmore" Journal dementia and geriatric cognitive disorders
6 results on '"Peter, Passmore"'

1. Elevated Platelet β-Secretase Activity in Mild Cognitive Impairment

Author

Anthony Peter Passmore, G.B. Irvine, W.W. Liu, Janet A. Johnston, Suzanne P. Murphy, David T.R. Coulson, David Craig, and Stephen Todd

Subjects
Blood Platelets, Male, medicine.medical_specialty, Cognitive Neuroscience, Neuropsychological Tests, Severity of Illness Index, Degenerative disease, Internal medicine, Amyloid precursor protein, Humans, Medicine, Dementia, Platelet, Platelet activation, Aged, biology, business.industry, Cognitive disorder, Neurodegeneration, Brain, medicine.disease, Psychiatry and Mental health, Endocrinology, ROC Curve, Nerve Degeneration, biology.protein, Biomarker (medicine), Female, Amyloid Precursor Protein Secretases, Geriatrics and Gerontology, Cognition Disorders, business
Abstract

Background/Aims: We have recently reported that platelet activity of the rate-limiting enzyme for β-amyloid peptide production is elevated in established Alzheimer’s disease. Laboratory investigation of the very early stages of dementia provides an opportunity to investigate pathological mechanisms before advanced disease hinders interpretation. Mild cognitive impairment (MCI) exists prior to obvious dementia, and is associated with increased risk of conversion to overt disease. Methods: We developed and used a fluorimetric assay to quantify platelet membrane β-secretase activity in 52 patients with MCI and 75 controls. Results: Platelet membrane β-secretase activity was 24% higher in individuals with MCI compared to controls (p = 0.001, unpaired t test with Welch correction). Conclusion: Elevated platelet β-secretase activity in subjects with MCI is an area for further study in relation to the etiology and diagnosis of MCI.

Published
2007
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2. Association Analysis of Apolipoprotein E Genotype and Risk of Depressive Symptoms in Alzheimer’s Disease

Author

Stephen P. McIlroy, A. Peter Passmore, David Craig, and Dominic J. Hart

Subjects
Male, Risk, Apolipoprotein E, medicine.medical_specialty, Genotype, Cognitive Neuroscience, Apolipoprotein E4, Population, Northern Ireland, Disease, Neuropsychological Tests, Dysphoria, Cohort Studies, Apolipoproteins E, Gene Frequency, Alzheimer Disease, Internal medicine, medicine, History of depression, Humans, Dementia, Risk factor, education, Psychiatry, Depression (differential diagnoses), Aged, Aged, 80 and over, education.field_of_study, Depression, medicine.disease, Psychiatry and Mental health, Female, Geriatrics and Gerontology, medicine.symptom, Psychology
Abstract

Objectives: Behavioural and psychological symptoms of dementia (BPSD) are potent predictors of carer distress and admission to institutional care. In Alzheimer’s disease (AD), depressive symptoms are one of the most common complaints affecting around 50% of all patients. There is speculation these symptoms result from known genetic risk factors for AD, therefore we investigated the role of apolipoprotein E Ε4 in the aetiology of depression in AD. Methods: In this well-characterised cohort (n = 404) from the relatively genetically homogeneous Northern Ireland population, we tested the hypothesis that genetic variants of apolipoprotein E influence the risk for depressive symptoms in AD patients using the Neuropsychiatric Inventory (NPI-D) to determine the presence of depressive symptoms during the dementing illness. Results: A total of 55% of patients exhibited a history of depression/dysphoria during the course of the illness as gathered by the NPI-D questionnaire. Forty-six percent were suffering from depression/dysphoria when the analysis was restricted to the month prior to interview. No statistically significant association between genotypes or alleles of apolipoprotein E and depression/dysphoria in AD was observed, nor was any association noted between the presence of severe symptoms and genotypes/alleles of apolipoprotein E. Conclusions: These results suggest apolipoprotein E genotype creates no additional risk for depressive symptoms in AD.

Published
2005
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3. No Evidence of Endothelial Dysfunction in Patients with Alzheimer’s Disease

Author

G D Johnston, Anthony Peter Passmore, Daniel F. McAuley, and B M McGleenon

Subjects
Male, Nitroprusside, medicine.medical_specialty, Pathology, Brachial Artery, Endothelium, Vasodilator Agents, Cognitive Neuroscience, Hemodynamics, Central nervous system disease, Alzheimer Disease, Internal medicine, medicine, Humans, Infusions, Intra-Arterial, Vascular Diseases, Endothelial dysfunction, Aged, Aged, 80 and over, Dose-Response Relationship, Drug, business.industry, Middle Aged, medicine.disease, Acetylcholine, Plethysmography, body regions, Forearm, Psychiatry and Mental health, medicine.anatomical_structure, Regional Blood Flow, Case-Control Studies, Circulatory system, Cardiology, Female, Endothelium, Vascular, Sodium nitroprusside, Geriatrics and Gerontology, Alzheimer's disease, business, medicine.drug, Blood vessel
Abstract

In view of accumulating evidence of vascular pathology in Alzheimer’s disease (AD), we tested the hypothesis that AD patients have impaired endothelial function. This was assessed using the technique of strain-gauge venous occlusion plethysmography, which measures forearm blood flow (FBF). Intra-arterial (brachial) infusion of acetylcholine (ACh) and sodium nitroprusside (SNP) was used to assess local endothelial dependent and independent responses, respectively. There was no difference in the basal FBF of patients and controls. ACh and SNP caused dose-related increases in FBF from baseline, but no difference was recorded between the AD and control group. This study provides no evidence of endothelial dysfunction in the systemic circulation of patients with AD.

Published
2000
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4. Contents Vol. 24, 2007

Author

Steen G. Hasselbalch, Gunhild Waldemar, Roger Bullock, Stephen Todd, Raymond L.C. Vogels, T.K. Nilsson, Eric Salmon, Ann-Sofie Teller, Oriana Pelati, Anjan Chatterjee, Samantha Pradelli, Ming-X Tang, Kazi Elina, Enzo Grossi, Bruno Vellas, Laura Bracco, Geoffrey K. Aguirre, Peachie Moore, Carolina Piccini, J. McGuire, H. Branch Coslett, David J. Libon, S. Murphy, Michela Baccini, S.D. Rountree, Ingun Ulstein, Barbera van Harten, Miriam Caputo, Frans R.J. Verhey, Emma Reynish, Sara Ercolani, E.J. Darby, Richard Mayeux, Yaakov Stern, Pierre Jean Ousset, Lauren Massimo, W.W. Liu, Rita Savarè, David Craig, Janet A. Johnston, Sandro Sorbi, D.T.R. Coulson, Marina Boziki, Clive Holmes, S.C. Waring, W.C. Chan, Wiesje M. van der Flier, Anna Marriott, Philip Scheltens, Leiv Sandvik, V.N. Podust, Luc De Vreese, G.B. Irvine, Anthony Peter Passmore, Joseph H. Lee, E. Mariani, Philippe Robert, Paolo Caffarra, Vincent Camus, Flavio Nobili, M. Caputo, Alida A. Gouw, Aaron Rice, Anja Hviid Simonsen, Patrizia Mecocci, P. Mecocci, U. Senin, F.T. Feliziani, Peter Høgh, Nicole Schupf, Elisabeth Kapaki, Peter Paul De Deyn, Nicola Girtler, Debby Collins, Magda Tsolaki, Knut Engedal, E. J. Byrne, D.F. Vitale, Henry C. Weinstein, Luisa Vesely, Renata Cerutti, Jutta M. Schroeder-Tanka, N.-O. Hagnelius, Rachelle S. Doody, Massimo Franceschi, Pauline Aalten, Beverly Johnson, Joukje M. Oosterman, Francesca Mangialasche, Torgeir Bruun Wyller, Murray Grossman, Benedetta Nacmias, Catherine S Hurt, P.J. Lupo, R. Monastero, D. Vassilopoulos, Vincent Santana, Giovanni B. Frisoni, Federica Biancucci, Silvia Bagnoli, and Valentina Bessi

Subjects
Psychiatry and Mental health, Cognitive Neuroscience, Geriatrics and Gerontology
Published
2007
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5. Subject Index Vol. 24, 2007

Author

Miriam Caputo, Knut Engedal, D.F. Vitale, Anna Marriott, Henry C. Weinstein, Nicole Schupf, Emma Reynish, N.-O. Hagnelius, Giovanni B. Frisoni, Federica Biancucci, Oriana Pelati, David J. Libon, Beverly Johnson, Patrizia Mecocci, P. Mecocci, Sara Ercolani, W.C. Chan, Paolo Caffarra, S.D. Rountree, Jutta M. Schroeder-Tanka, E. Mariani, Philippe Robert, Geoffrey K. Aguirre, Steen G. Hasselbalch, Francesca Mangialasche, Joseph H. Lee, Murray Grossman, M. Caputo, Raymond L.C. Vogels, Benedetta Nacmias, F.T. Feliziani, Peter Høgh, Vincent Camus, Sandro Sorbi, Torgeir Bruun Wyller, Philip Scheltens, Vincent Santana, Joukje M. Oosterman, E.J. Darby, Ming-X Tang, D.T.R. Coulson, Ann-Sofie Teller, U. Senin, S.C. Waring, Kazi Elina, Janet A. Johnston, Catherine S Hurt, Wiesje M. van der Flier, Richard Mayeux, David Craig, Gunhild Waldemar, Clive Holmes, Anthony Peter Passmore, T.K. Nilsson, P.J. Lupo, Peter Paul De Deyn, Marina Boziki, Eric Salmon, Laura Bracco, G.B. Irvine, Bruno Vellas, Luc De Vreese, Magda Tsolaki, Anja Hviid Simonsen, Peachie Moore, Elisabeth Kapaki, H. Branch Coslett, Michela Baccini, Luisa Vesely, W.W. Liu, E. J. Byrne, Yaakov Stern, Nicola Girtler, S. Murphy, R. Monastero, Ingun Ulstein, Barbera van Harten, D. Vassilopoulos, V.N. Podust, Pierre Jean Ousset, Rita Savarè, Lauren Massimo, Debby Collins, Aaron Rice, Alida A. Gouw, Flavio Nobili, Stephen Todd, J. McGuire, Frans R.J. Verhey, Enzo Grossi, Carolina Piccini, Anjan Chatterjee, Samantha Pradelli, Pauline Aalten, Roger Bullock, Renata Cerutti, Rachelle S. Doody, Massimo Franceschi, Leiv Sandvik, Silvia Bagnoli, and Valentina Bessi

Subjects
Psychiatry and Mental health, Index (economics), Cognitive Neuroscience, Statistics, Subject (documents), Geriatrics and Gerontology, Mathematics
Published
2007
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6. APOE Genotype and Alzheimer´s Disease

Author

María Ólafsdóttir, G D Johnston, Gunter P. Eckert, Paul G. Ince, Robert H. Perry, Walter E. Müller, Ian G. McKeith, Richard A. Armstrong, Martin R. Farlow, Pierre L. Le Bars, Meinhard Kieser, John T. O'Brien, Alan C. Swann, B M McGleenon, David J. Burn, A. Maras, Naruhiko Maki, Kenjiro Komori, Peter L. Lantos, Manabu Ikeda, Maria Caterina Silveri, Wagner F. Gattaz, Akihiko Nebu, Camillo Marra, Jan Marcusson, Clive Holmes, P. Lantos, Nobutsugu Hirono, Anthony Peter Passmore, Nigel J. Cairns, Clive Ballard, Ingmar Skoog, Kurt Z. Itil, David Neill, Hirotaka Tanabe, Guido Gainotti, Kazuhiko Hokoishi, P.A. Cyrus, and Daniel F. McAuley

Subjects
Apolipoprotein E, Psychiatry and Mental health, medicine.medical_specialty, business.industry, Cognitive Neuroscience, Immunology, Genotype, Medicine, Disease, Geriatrics and Gerontology, business, Psychiatry
Published
2000
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