1. Clinicopathological correlates of Alzheimer's disease in a general autopsy series from Brazil
- Author
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Lea Tenenholz Grinberg, Renata Eloah de Lucena Ferretti, Renata E.P. Leite, Jose Marcelo Farfel, Silmara P. Pacheco, Ana Teresa Di Lorenzo Alho, Renata P. Grisoli, Heidy T.M. Matos, Eliza G. Moreira, Erika S. Balbino, Katia C. Oliveira, Sergio Rosemberg, Heráclito Barbosa Carvalho, Carlos Augusto G. Pasquallucci, Paulo Hilario N. Saldiva, Wilson Jacob-Filho, and Ricardo Nitrini
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Alzheimer's disease ,dementia ,diagnostic criteria ,neuropathological criteria ,brain bank ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract The current neuropathological staging models of Alzheimer's disease (AD) have been developed within the last 20 years. Nevertheless, they were mostly tested on Caucasians of Northern European ancestry or on Asians. Objective: To verify which of the accepted neuropathologic criteria best discriminates AD from normal aging in a well characterized Brazilian clinicopathological series. Methods: A random sample consisting of 89 subjects belonging to the Brazilian Brain Bank of the Aging Brain Study were clinically and neuropathologically fully assessed using immunohistochemistry. Clinical and functional statuses were assessed by interviewing a reliable informant. The Clinical dementia rating scale (CDR) was compared to Braak and Braak stage, the consortium to establish a registry for Alzheimer's disease (CERAD) score and NIA-Reagan (National Institute of Aging - Reagan Institute) score. Subjects with a neuropathologic diagnosis other then AD were excluded (n=27). Results: The CDR score distribution for the 62 selected subjects was as follows: CDR0=39, CDR0.5=9, CDR³1=14. There were no differences regarding age, gender and education among the groups. CDR score correlated best with the CERAD score (r=0.5303; p
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