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2 results on '"SREBP-1c, sterol regulatory element-binding protein 1c"'

1. Retinoid regulated macrophage cholesterol efflux involves the steroidogenic acute regulatory protein.

Author

Manna PR

Abstract

Elimination of excess cholesteryl esters from macrophage-derived foam cells is known to be a key process in limiting plaque stability and progression of atherosclerotic lesions. We have recently demonstrated that regulation of retinoid mediated cholesterol efflux is influenced by liver X receptor (LXR) signaling in mouse macrophages (Manna, P.R. et al., 2015, Biochem. Biophys. Res. Commun., 464:312-317). The data presented in this article evaluate the importance of the steroidogenic acute regulatory protein (StAR) in retinoid mediated macrophage cholesterol efflux. Overexpression of StAR in mouse RAW 264.7 macrophages increased the effects of both all-trans retinoic acid (atRA) and 9-cis RA on cholesterol efflux, suggesting StAR enhances the efficacy of retinoic acid receptor (RAR) and/or retinoid X receptor (RXR) ligands. Additional data revealed that atRA enhances (Bu)2cAMP induced StAR and ATP-binding cassette transporter A1 protein levels. Treatment of macrophages transfected with an LXRE reporter plasmid (pLXREx3-Luc) was found to induce the effects of RAR and RXR analogs on LXR activity.

Published
2016
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2. Retinoid regulated macrophage cholesterol efflux involves the steroidogenic acute regulatory protein

Author

Pulak R. Manna

Subjects
0301 basic medicine, medicine.medical_specialty, StAR, medicine.drug_class, RXR, retinoid X receptor, Retinoic acid, SREBP-1c, sterol regulatory element-binding protein 1c, RXR, ABCA1, 030204 cardiovascular system & hematology, Biology, Retinoid X receptor, lcsh:Computer applications to medicine. Medical informatics, 03 medical and health sciences, chemistry.chemical_compound, StAR, steroidogenic acute regulatory protein, Retinoids, 0302 clinical medicine, Internal medicine, medicine, Retinoid, Cholesterol efflux, lcsh:Science (General), Liver X receptor, Apo-A1, apolipoprotein A1, Data Article, (Bu)2cAMP, dibutyryl cAMP, RAR, retinoic acid receptor, Multidisciplinary, Steroidogenic acute regulatory protein, Macrophages, ABCA1, ATP-binding cassette transporter A1, Cell biology, Retinoic acid receptor, 030104 developmental biology, Endocrinology, chemistry, retinoids, retinoic acid (RA) and its derivatives, biology.protein, lcsh:R858-859.7, lipids (amino acids, peptides, and proteins), Retinoid X receptor beta, LXR, liver X receptor, atRA, all-trans RA, RAR, lcsh:Q1-390
Abstract

Elimination of excess cholesteryl esters from macrophage-derived foam cells is known to be a key process in limiting plaque stability and progression of atherosclerotic lesions. We have recently demonstrated that regulation of retinoid mediated cholesterol efflux is influenced by liver X receptor (LXR) signaling in mouse macrophages (Manna, P.R. et al., 2015, Biochem. Biophys. Res. Commun., 464:312-317). The data presented in this article evaluate the importance of the steroidogenic acute regulatory protein (StAR) in retinoid mediated macrophage cholesterol efflux. Overexpression of StAR in mouse RAW 264.7 macrophages increased the effects of both all-trans retinoic acid (atRA) and 9-cis RA on cholesterol efflux, suggesting StAR enhances the efficacy of retinoic acid receptor (RAR) and/or retinoid X receptor (RXR) ligands. Additional data revealed that atRA enhances (Bu)2cAMP induced StAR and ATP-binding cassette transporter A1 protein levels. Treatment of macrophages transfected with an LXRE reporter plasmid (pLXREx3-Luc) was found to induce the effects of RAR and RXR analogs on LXR activity. Keywords: Macrophages, Retinoids, StAR, Cholesterol efflux, RAR, RXR, ABCA1

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