1. Nanoparticles of metal-organic cages designed to encapsulate platinum-based anticancer agents
- Author
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Jacob T. Shelley, Zhizhou Yue, Frederick Nielsen, Morgan Stilgenbauer, Yao-Rong Zheng, Han Wang, Min Gao, and David J. Bowers
- Subjects
Nanoparticle ,chemistry.chemical_element ,Antineoplastic Agents ,Apoptosis ,Capsules ,010402 general chemistry ,01 natural sciences ,Inorganic Chemistry ,Metal ,Organometallic Compounds ,Humans ,Prodrugs ,Drug Carriers ,010405 organic chemistry ,Chemistry ,Cationic polymerization ,Prodrug ,Combinatorial chemistry ,0104 chemical sciences ,Anionic addition polymerization ,visual_art ,visual_art.visual_art_medium ,Nanoparticles ,Cisplatin ,Platinum ,HeLa Cells - Abstract
We present a novel design to use metal-organic cages (MOCs) to encapsulate Pt-based anticancer agents for delivery. A fluorescein-conjugated Pt(iv) prodrug of cisplatin is developed for its encapsulation in a cationic MOC via host-guest interactions, which then forms drug-loaded nanoparticles with an anionic polymer.
- Published
- 2017