1. DNA-binding drugs caught in action: the latest 3D pictures of drug-DNA complexes.
- Author
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D. Roeland Boer, Albert Canals, and Miquel Coll
- Subjects
- *
NUCLEOTIDE sequence , *X-ray crystallography , *NUCLEAR magnetic resonance spectroscopy , *MOLECULAR weights , *NUCLEIC acids , *OLIGONUCLEOTIDES , *POLYPEPTIDES - Abstract
In this paper, we review recent DNA-binding agents that are expected to influence the field of DNA-targeting. We restrict ourselves to binders for which the three-dimensional structure in complex with DNA or RNA has been determined by X-ray crystallography or NMR. Furthermore, we primarily focus on unprecedented ways of targeting peculiar DNA structures, such as junctions, quadruplexes, and duplex DNAs different from the B-form. Classical binding modes of small molecular weight compounds to DNA, i.e.groove binding, intercalation and covalent addition are discussed in those cases where the structures represent a novelty. In addition, we review 3D structures of triple-stranded DNA, of the so-called Peptide Nucleic Acids (PNAs), which are oligonucleotide bases linked by a polypeptide backbone, and of aptamers, which are DNA or RNA receptors that are designed combinatorially. A discussion on perspectives in the field of DNA-targeting and on sequence recognition is also provided. [ABSTRACT FROM AUTHOR]
- Published
- 2008