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The genetic determination of components of the metabolic syndrome has been studied based on materials including clinical and genealogical data on 510 patients with type 2 diabetes mellitus, 445 individuals with essential hypertension, and 239 abdominal obesity patients and their first-degree relatives. The results of the component analysis revealed the significance of genetic factors in determining the diseases under study and allowed us to conjecture that there exists an interlocus interaction in their genetic control system. Testing Ch. Smith’s model revealed the genetic independence of the above conditions and allowed us to determine the coefficient of genetic relatedness of the pathologies under study. [ABSTRACT FROM AUTHOR]

The Q192R polymorphism of PON-1 gene was genotyped in 96 individuals with diabetes mellitus type 2 (T2DM) and 123 nondiabetic control individuals from Kharkiv. Allele frequencies do not differ significantly between T2DM ( p = 0.65 and p = 0.35) and healthy individuals ( p = 0.70 and p = 0.30). Genotype distribution for healthy people complies with the Hardy-Weinberg equilibrium, and the T2DM patients have excess of both homozygotes and deficiency of heterozygotes. The risk of T2DM for QQ homozygotes is 1.47 times higher and for QR heterozygote is twice lower than the population average (2%). The RR homozygote individuals have statistically insignificant, 1.86 times, increase in T2DM risk. [ABSTRACT FROM AUTHOR]