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1. Genome-derived cytosolic DNA contributes to type I interferon expression and immunogenicity of B-cell lymphoma cells

Author

Muznah Khatoo, Samantha S.W. Ho, Florence S.G. Cheung, Nikki Y. Tan, Yu J. Shen, Stephan Gasser, and Christine Xing’Er Koo

Subjects
Lymphoma, B-Cell, DNA repair, Immunology, Biochemistry, Endonuclease, chemistry.chemical_compound, Extrachromosomal DNA, Cell Line, Tumor, medicine, Immunology and Allergy, Humans, Protein–DNA interaction, B-cell lymphoma, Molecular Biology, Genome, biology, RNA, Hematology, DNA, medicine.disease, Molecular biology, Proliferating cell nuclear antigen, chemistry, Interferon Type I, biology.protein
Abstract

We recently provided evidence that genome-derived DNA is present in the cytosol of many tumor cells. Genomic loci that give rise to cytosolic DNA can potentially form non-B DNA structures including triple-stranded RNA:DNA structures (R-loops). The RNA:DNA-specific endonuclease RNaseh1 reduced the levels of cytosolic DNA and type I interferon-dependent rejection of B-cell lymphoma suggesting that cytosolic DNA may contribute to immune surveillance of B-cell lymphoma.

Published
2015

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