1. Th22 cytokines and yellow fever: Possible implications for the immunopathogenesis of human liver infection.
- Author
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Mendes CCH, de Sousa JR, Olímpio FA, Falcão LFM, Carvalho MLG, da Costa Lopes J, Martins Filho AJ, do Socorro Cabral Miranda V, Dos Santos LC, da Silva Vilacoert FS, Galúcio VCA, do Socorro da Silva Azevedo R, Martins LC, Duarte MIS, da Costa Vasconcelos PF, and Quaresma JAS
- Subjects
- Cytokines, Humans, Yellow fever virus, Communicable Diseases, Flavivirus, Liver Diseases, Yellow Fever pathology
- Abstract
Yellow fever (YF) is an infectious disease considered a public health problem in tropical and subtropical areas. YF has many pathophysiological events that are correlated with the host immune response. In this study, the in situ Th22 cytokine profile was evaluated. Liver tissue samples were collected from 21 YFV-positive patients who died of the disease and five flavivirus-negative controls who died of other causes and whose hepatic parenchyma architecture was preserved. Immunohistochemical (IHC) analysis of tissues in the hepatic parenchyma of YF cases showed significantly higher expression of interleukin (IL)-22, IL-13, tumour necrosis factor-alpha, and FGF basic (FGF b) in YFV-positive cases than that in flavivirus-negative controls. These results indicate that the response of Th22 cytokines emerges as an alternative for a better understanding of adaptive immunity in the hepatic parenchyma, highlighting the role of cytokines in the repair and suppressive responses in the immunopathogenesis of YFV infection., (Copyright © 2022 Elsevier Ltd. All rights reserved.)
- Published
- 2022
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