1. Emerging roles for IL-11 in inflammatory diseases
- Author
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Ka Yee Fung, Michael D. W. Griffin, Clara C. Kosasih, Tracy L Putoczki, Ian P. Wicks, Cynthia Louis, and Riley D. Metcalfe
- Subjects
Autoimmune disease ,Inflammation ,business.industry ,Multiple sclerosis ,Immunology ,Arthritis ,Hematology ,medicine.disease ,Interleukin-11 ,Biochemistry ,Inflammatory bowel disease ,Autoimmune Diseases ,Pathogenesis ,Psoriasis ,medicine ,Immunology and Allergy ,Animals ,Humans ,Colitis ,medicine.symptom ,business ,Molecular Biology - Abstract
Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also associated with several non-malignant inflammatory diseases where its function remains less well-characterized. Here, we summarize current literature surrounding the contribution of IL-11 to the pathogenesis of autoimmune inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, diabetes and systemic sclerosis, as well as other chronic inflammatory conditions such as periodontitis, asthma, chronic obstructive pulmonary disease, psoriasis and colitis.
- Published
- 2021