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This article focuses on the localization of Madcam1 gene to rat chromosome 7q11.2→q12 by fluorescence in situ hybridization, somatic cell hybrids and linkage analysis. MAdCAM-1, the mucosal vascular address in cell adhesion molecule-1, is preferentially expressed on endothelial cells of high endothelial venules in mucosal lymphoid tissues such as Peyer's patches and mesenteric lymph nodes. It recruits lymphocytes into mucosal lymphoid and inflamed tissues by binding with the lymphocyte integrin α4&b.beta;. Murine and human MAdCAM-1 genes have been cloned and their roles are discussed not only in the multistep process of lymphocyte homing but also in various inflammatory diseases.