1. Post-Burn Pruritus and Its Management—Current and New Avenues for Treatment
- Author
-
Gil Yosipovitch and Emilie Fowler
- Subjects
medicine.medical_specialty ,Burn injury ,integumentary system ,Gabapentin ,business.industry ,Rehabilitation ,Pregabalin ,Treatment options ,030208 emergency & critical care medicine ,Botulinum toxin ,03 medical and health sciences ,0302 clinical medicine ,Opioid ,medicine ,Orthopedics and Sports Medicine ,Surgery ,030212 general & internal medicine ,skin and connective tissue diseases ,Intensive care medicine ,business ,Burn scar ,medicine.drug - Abstract
This article seeks to review the current literature on post-burn pruritus and its treatments, as well as to propose new treatments that may be of potential benefit for these patients. Post-burn pruritus has been reported to affect as many as 93% of patients after a burn injury. Pruritus is extremely distressing to these patients, yet the current state of treatment, mostly antihistamines and emollients, is still widely ineffective in providing relief of itch. Therapies that are effective in treating pruritus and that may act as superior treatment options for patients suffering from post-burn pruritus include gabapentin and pregabalin, topical ketamine-lidocaine-amitriptyline, opioid medications, neurokinin-1 inhibitors, antidepressants, anti-cytokines, PAR-2 inhibitors, and botulinum toxin among others.
- Published
- 2019
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