1. Protective Effect of Hispolon on Postoperative Cognitive Dysfunction in a Sevoflurane-Induced HT-22 Cell Model.
- Author
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Hua Wang, Yanan Ji, Chuanju Liu, Jie Gao, and Junjiao Hu
- Subjects
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COGNITION disorders , *POLYPHENOLS , *ANTI-inflammatory agents , *MITOCHONDRIAL pathology , *SURGICAL complications , *APOPTOSIS , *HYPOGLYCEMIC agents , *TREATMENT effectiveness , *OXIDATIVE stress , *SEVOFLURANE , *CELL lines , *MOLECULAR structure - Abstract
Inhalation of the anesthetic sevoflurane leads to neuronal apoptosis, oxidative stress, and cognitive disorders, resulting in post-operative cognitive dysfunction. Hispolon, a natural polyphenol from Phellinus linteus, has been reported to exhibit anticancer, antidiabetic, antioxidant, antiviral, and anti-inflammatory activities. However, its functions in modulating sevoflurane-stimulated neuronal toxicity remain to be examined. To this end, using sevoflurane-treated HT22 cells as a model of postoperative cognitive dysfunction, we have examined the effect of hispolon. Our results show a diminution of the sevoflurane-induced rise in mitochondrial dysfunction, oxidative stress, cell toxicity, and apoptosis in HT22 cells by hispolon. In conclusion, these data suggest that hispolon may be a potential drug for treating postoperative cognitive dysfunction. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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