1. Targeting Breast Cancer Stem Cells: A Methodological Perspective
- Author
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Inés Velázquez-Quesada, Sonia Mayra Pérez-Tapia, Marco A. Velasco-Velázquez, and Luz X. Vásquez-Bochm
- Subjects
business.industry ,Medicine (miscellaneous) ,Antineoplastic Agents ,Breast Neoplasms ,Tumor cells ,General Medicine ,Self renewal ,medicine.disease ,Tumor heterogeneity ,Breast cancer ,Cancer stem cell ,Biological property ,Neoplastic Stem Cells ,Cancer research ,Animals ,Humans ,Medicine ,Female ,Experimental methods ,Stem cell ,business - Abstract
Cancer Stem Cells (CSCs) constitute a subpopulation at the top of the tumor cell hierarchy that contributes to tumor heterogeneity and is uniquely capable of seeding new tumors. Because of their biological properties, CSCs have been pointed out as therapeutic targets for the development of new therapies against breast cancer. The identification of drugs that selectively target breast CSCs requires a clear understanding of their biological functions and the experimental methods to evaluate such hallmarks. Herein, we review the methods to study breast CSCs properties and discuss their value in the preclinical evaluation of CSC-targeting drugs.
- Published
- 2019
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