1. Alginates in Pharmaceutics and Biomedicine: Is the Future so Bright?
- Author
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Giulia Falabella, Riccardo Calafiore, Maria Bodo, Stefano Giovagnoli, Mario Calvitti, Giovanni Luca, Maurizio Ricci, Giuseppe Basta, Aurelie Marie Madeleine Schoubben, Francesca Mancuso, Paolo Blasi, Iva Arato, Giovagnoli S., Luca G., Blasi P., Mancuso F., Schoubben A., Arato I., Calvitti M., Falabella G., Basta G., Bodo M., Calafiore R., and Ricci M.
- Subjects
Engineering ,Biopolymer ,Alginates ,Alginate, microencapsulation, alginate drug delivery systems, cell microencapsulation, clinical studies, cell transplantation ,Nanotechnology ,Clinical studie ,alginate drug delivery systems ,Alginate drug delivery system ,Biopolymers ,Drug Delivery Systems ,Cell transplantation ,Biological property ,Drug Discovery ,Animals ,Humans ,clinical studies ,Microencapsulation ,Drug Carrier ,Biomedicine ,Pharmacology ,Drug Carriers ,Cell microencapsulation ,Animal ,business.industry ,Alginate ,Biotechnology ,Diabetes Mellitus, Type 1 ,Drug Design ,Drug delivery ,Pharmaceutics ,business ,Human - Abstract
Alginate represents one of the most appealing biopolymers for pharmaceutical and biomedical applications. Alginate as a biomaterial for clinical use has been established, although not free from issues. Here we provide a critical review on some of the main recent advances in alginate research in drug delivery and its prominent role in cell microencapsulation for the treatment of diseases, such as type 1 diabetes mellitus. A brief description of the basic properties of the polymer will be provided as well. Based on our experience and contributions, as well as wide research in the field, the correlation between physicochemical and biological properties of alginate systems and clinical outcomes will be investigated and discussed to address the actual future clinical impact of alginate-based delivery strategies.
- Published
- 2015
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