1. Protection against dengue virus requires a sustained balance of antibody and T cell responses.
- Author
-
Valentine KM, Croft M, and Shresta S
- Subjects
- Animals, Antibody-Dependent Enhancement, Dengue virology, Dengue Virus genetics, Humans, Antibodies, Viral immunology, Dengue immunology, Dengue Virus physiology, T-Lymphocytes immunology
- Abstract
Pre-existing immunity to dengue virus (DENV) can either protect against or exacerbate, a phenomenon known as antibody dependent enhancement (ADE), a secondary DENV infection. DENV, as an escalating health problem worldwide, has increased the urgency to understand the precise parameters shaping the anti-DENV antibody (Ab) and T cell responses, thereby tipping the balance towards protection versus pathogenesis. Herein, we present the current state of knowledge of about the interplay between the Ab and T cell responses that dictate the outcome of DENV infection and discuss how this newfound knowledge is reshaping strategies for developing safe and effective DENV vaccines., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
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