9 results on '"Pipitone N"'
Search Results
2. Systemic vasculitis: state of the art and emerging concepts.
- Author
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Pipitone N and Salvarani C
- Published
- 2006
- Full Text
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3. New approaches in the treatment of Adamantiades-Behçet's disease
- Author
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Ignazio Olivieri, Fabrizio Cantini, Carlo Salvarani, Giovanni Triolo, Nicolò Pipitone, PIPITONE N, OLIVIERI I, CANTINI F, TRIOLO G, and SALVARANI C
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medicine.medical_specialty ,Mucocutaneous zone ,Arthritis ,Behcet's disease ,Disease ,Interferon alpha-2 ,Receptors, Tumor Necrosis Factor ,law.invention ,Etanercept ,Rheumatology ,Randomized controlled trial ,law ,Antibodies, Monoclonal ,Behcet Syndrome ,Chaperonin 60 ,Humans ,Immunoglobulin G ,Immunologic Factors ,Interferon-alpha ,Recombinant Proteins ,medicine ,IFN-α2a ,business.industry ,medicine.disease ,Dermatology ,eye diseases ,Infliximab ,Adamantiades-Behçet's disease ,stomatognathic diseases ,Immunology ,Tumour necrosis factor ,business ,Tolerization ,Uveitis ,medicine.drug - Abstract
Purpose of review To update clinicians on the recent advances in the treatment of Adamantiades-Behcet's disease. Recent findings Interferon-α-2a and infliximab have proved able to induce prompt remission in the vast majority of Adamantiades-Behcet's patients with DMARD-resistant uveoretinitis. Efficacy of interferon-α-2a has also been reported for mucocutaneous lesions, arthritis, and (more anecdotally) for neuro-Behcet, while results from small case series suggest that infliximab is beneficial for mucocutaneous lesions and (more anecdotally) for arthritis and gastro-intestinal manifestations. Two cases of neuro-Behcet treated with infliximab showed a complete resolution. Finally, in a randomized controlled trial of patients with mucocutaneous, arthritic manifestations, or both, etanercept effectively suppressed mucocutaneous lesions. Recent findings A different approach is tolerization by oral administration of the 336–351 peptide of the human heat shock protein 60 (thought to have a pathogenic role in Adamantiades-Behcet's disease-associated uveitis), linked to recombinant cholera B-toxin B-subunit. Prelimary results have shown that tolerization is safe and effective in preventing relapses of uveitis. Summary Biologic agents have proved effectiive in patients resistant to conventional treatment. However, disease subsets characterized by severe morbidity and mortality such as vasculo-Behcet and neuro-Behcet still pose major therapeutic challenges. Further studies are needed to devise better treatment strategies for severe Adamantiades-Behcet's disease.
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- 2005
4. The role of PET/CT in disease activity assessment in patients with large vessel vasculitis.
- Author
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Galli E, Pipitone N, and Salvarani C
- Subjects
- Humans, Positron Emission Tomography Computed Tomography, Fluorodeoxyglucose F18, Arteries, Positron-Emission Tomography, Takayasu Arteritis diagnostic imaging, Giant Cell Arteritis diagnostic imaging
- Abstract
Purpose of Review: The aim of this article was to review the recent contributions on the role of PET in assessing disease activity in patients with large-vessel vasculitis (giant cell arteritis and Takayasu arteritis)., Recent Findings: 18 FDG (fluorodeoxyglucose) vascular uptake in large-vessel vasculitis at PET shows moderate correlation with clinical indices, laboratory markers and signs of arterial involvement at morphological imaging. Limited data may suggest that 18 FDG (fluorodeoxyglucose) vascular uptake could predict relapses and (in Takayasu arteritis) the development of new angiographic vascular lesions. PET appears to be in general sensitive to change after treatment., Summary: While the role of PET in diagnosis large-vessel vasculitis is established, its role in evaluating disease activity is less clear-cut. PET may be used as an ancillary technique, but a comprehensive assessment, including clinical, laboratory and morphological imaging is still required to monitor patients with large-vessel vasculitis over time., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Published
- 2023
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5. Up-to-date treatment and management of myositis.
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Pipitone N and Salvarani C
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- Dermatomyositis drug therapy, Disease Management, Humans, Polymyositis drug therapy, Treatment Outcome, Anti-Inflammatory Agents therapeutic use, Biological Products therapeutic use, Glucocorticoids therapeutic use, Myositis drug therapy
- Abstract
Purpose of Review: Myositis, or idiopathic inflammatory myopathy, is an overarching concept that includes dermatomyositis, polymyositis, immune-mediated necrotizing myopathy and the antisynthetase syndrome. Glucocorticoids are still considered the mainstay of treatment of myositis but some patients require add-on immunosuppressive therapy because of insufficient response to glucocorticoids, relapses when glucocorticoids are tapered, or because they incur glucocorticoid-related side effects., Recent Findings: The goal of this article was to review (PubMed search from January 2019 through June 2020) the efficacy and safety of standard and novel agents used in adult dermatomyositis, polymyositis, immune-mediated necrotizing myopathy and the antisynthetase syndrome., Summary: Established therapies beyond glucocorticoids continue to have a major role in managing patients with myositis. In addition, novel agents are being tried for refractory manifestations of myositis.
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- 2020
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6. Value of MRI in diagnostics and evaluation of myositis.
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Pipitone N
- Subjects
- Chronic Disease, Diagnosis, Differential, Elasticity Imaging Techniques, Humans, Magnetic Resonance Imaging methods, Muscle Weakness etiology, Muscular Atrophy complications, Muscular Diseases diagnostic imaging, Myocarditis diagnostic imaging, Myositis complications, Myositis therapy, Myositis diagnostic imaging
- Abstract
Purpose of Review: This review aims at covering the role of muscle MRI in supporting the diagnosis of myositis, in aiding to differentiate it from other muscle disorders, and in monitoring myositis patients over time by assessing response to treatment and by discriminating between muscle inflammation and chronic damage., Recent Findings: MRI can assist in 'pattern recognition' of muscle involvement across numerous myopathies, including myositis. Novel applications of magnetic resonance such as cardiac MRI, MR elastography and blood oxigenation level-dependent magnetic resonance can shed light on different aspects of myositis and usefully complement conventional MRI in assessing patients with myositis., Summary: MRI can guide therapy by determining whether muscle weakness is related to edema (active inflammation) or muscle atrophy/fat replacement (chronic damage). There is a need to better standardize the assessment of MRI findings in myositis to provide defined outcome measures for use in clinical trials. VIDEO ABSTRACT.
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- 2016
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7. Management of primary and secondary central nervous system vasculitis.
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Salvarani C, Pipitone N, and Hunder GG
- Subjects
- Humans, Systemic Vasculitis diagnosis, Vasculitis, Central Nervous System diagnosis
- Abstract
Purpose of Review: This article summarizes the current evidence on the management of primary and secondary central nervous system (CNS) vasculitis., Recent Findings: Two recent retrospective cohort studies have described the treatment and outcomes of patients with adult primary central nervous system vasculitis (PCNSV). Although the majority of the patients (>60%) responded to therapy with glucocorticoids alone or in conjunction with cyclophosphamide (CYC) and tended to improve during the follow-up period, an overall increased mortality was observed. The treatment response and the outcomes appeared primarily related to the size of the vessels involved in the inflammatory process. The involvement of small cortical/leptomeningeal vessels was associated with a more benign course, whereas the involvement of larger/proximal cerebral vessels was related to a less favorable prognosis and identified cases that should be treated more aggressively. Glucocorticoids combined with CYC are the mainstay of therapy for secondary CNS vasculitis. Observational studies have documented the efficacy of rituximab as induction therapy in patients with antineutrophil cytoplasm antibody-associated vasculitis (AAV) and CNS disease, while the role of antitumor necrosis factor (TNF) agents is more controversial. Case series have demonstrated the efficacy of anti-TNF agents in patients with neuro-Behçet's disease. Tocilizumab may also be effective in this condition., Summary: Recognition of findings at diagnosis that predict the course or outcomes of PCNSV may serve as guide for therapy. Biological agents may provide benefit to difficult-to-treat patients with CNS involvement secondary to AAV and Behçet's disease.
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- 2016
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8. Chronic periaortitis: a large-vessel vasculitis?
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Vaglio A, Pipitone N, and Salvarani C
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- Diagnosis, Differential, Fibrosis, Humans, Immunoglobulin G metabolism, Inflammation pathology, Retroperitoneal Fibrosis diagnosis, Retroperitoneal Fibrosis immunology, Retroperitoneal Fibrosis pathology, Vasculitis diagnosis, Vasculitis immunology, Vasculitis pathology, Retroperitoneal Fibrosis etiology, Vasculitis etiology
- Abstract
Purpose of Review: Chronic periaortitis is characterized by a fibro-inflammatory process spreading from the abdominal aorta and the iliac arteries. Originally, chronic periaortitis was considered a localized inflammatory response to severe aortic atherosclerosis. However, subsequent studies have shown that chronic periaortitis may also involve other arteries and present with features of auto-immune diseases. This article reviews the issue of large-vessel involvement in chronic periaortitis and its implications in the pathogenesis and nosography of the disease., Recent Findings: In many reports, chronic periaortitis has been shown to involve not only the aorto-iliac axis but also other vascular segments such as the thoracic aorta, the proximal epiaortic arteries, the coronary, renal, and mesenteric arteries. Thoracic aorta involvement may manifest as thoracic periaortitis with or without aneurysmal dilatation, or simply as thoracic aorta aneurysm. Thoracic periaortitis can also be a feature of the so-called IgG4-related systemic disease, with which chronic periaortitis may sometimes be associated. Histopathologic studies of chronic periaortitis show adventitial inflammation and fibrosis, vasculitis of vasa vasorum, and adventitial lymphoid follicles with germinal centers, suggesting that chronic periaortitis could be a primary aortitis. Genetic studies have demonstrated an association with HLA-DRB1*03, a marker of auto-immunity, and with the CCR5Δ32 polymorphism, which has been mapped to a Th2 response. Taken together, these findings support the notion of a primary inflammatory or immune-mediated disorder., Summary: Chronic periaortitis is an inflammatory or immune-mediated disorder characterized histopathologically by adventitial inflammation and clinically by variable involvement of different arteries, mainly of large caliber. These findings raise the issue of whether chronic periaortitis should be considered a large-vessel vasculitis.
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- 2011
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9. Improving therapeutic options for patients with giant cell arteritis.
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Pipitone N and Salvarani C
- Subjects
- Antibodies, Monoclonal therapeutic use, Azathioprine therapeutic use, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Therapy, Combination, Glucocorticoids adverse effects, Humans, Infliximab, Methotrexate therapeutic use, Randomized Controlled Trials as Topic, Tumor Necrosis Factor-alpha antagonists & inhibitors, Giant Cell Arteritis drug therapy, Glucocorticoids administration & dosage, Immunosuppressive Agents therapeutic use
- Abstract
Purpose of Review: Glucocorticoids remain the mainstay of treatment of giant cell arteritis. The aim of this review is to establish the optimal schedule of glucocorticoid administration, and to ascertain which other treatments may be used as glucocorticoid-sparing agents., Recent Findings: An initial dose of 40-60 mg/day of prednisone is usually adequate. Patients at risk of developing ischemic complications require dosages of around 1 mg/kg/day, whereas pulse glucocorticoid therapy is no more effective in preventing ischemic complications. In patients with longstanding disease or those at risk for glucocorticoid-related adverse events, methotrexate or azathioprine can be used as glucocorticoid-sparing drugs. Infliximab has been demonstrated to be efficacious in glucocorticoid-resistant disease in an open study, whereas a randomized controlled trial showed no efficacy in patients with recent-onset disease. Finally, two retrospective studies suggest that low-dose aspirin may decrease the rate of cranial ischemic complications secondary to giant cell arteritis., Summary: Glucocorticoids remain the cornerstone of therapy for giant cell arteritis. To achieve maximal efficacy but minimize glucocorticoid-related adverse reactions, dosage should be individually tailored. In patients with longstanding, recalcitrant disease, methotrexate, azathioprine or tumor necrosis factor-alpha inhibitors may be considered. Aspirin is recommended in all patients unless contraindicated. Osteoporosis prophylaxis should also be regularly implemented.
- Published
- 2008
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