1. The bacterial ribosome, a promising focus for structure-based drug design
- Author
-
David Justin Charles Knowles, Natalia Matassova, Alastair I H Murchie, and Nicolas Foloppe
- Subjects
Pharmacology ,Drug ,Molecular interactions ,Virtual screening ,Bacteria ,medicine.drug_class ,media_common.quotation_subject ,Bacterial ribosome ,Antibiotics ,Computational Biology ,Drug design ,Computational biology ,Biology ,Ribosome ,Combinatorial chemistry ,Anti-Bacterial Agents ,Drug Design ,Drug Discovery ,medicine ,Structure based ,Ribosomes ,media_common - Abstract
Recent crystal structures of the bacterial ribosome have identified the complex molecular interactions involved in antibiotic-ribosome recognition. Insights into the binding of aminoglycosides, macrolides, tetracyclines and other antibiotics provide opportunities for computational, structure-based approaches to be used in the design of appropriate modifications to existing antibiotics as well as in the discovery of completely new drug classes.
- Published
- 2002